Current topics in developmental biology. v. 80 / edited by Gerald P. Schatten. — Amsterdam : Elsevier Academic Press, c2008. – (58.12/C976/v.80)

Contents

    Contents
    
    Contributors ix
    Preface xi
    1 Similarities Between Angiogenesis and Neural Development: What Small Animal Models Can Tell Us
    I. Introduction 2
    II. Small Animal Models to Study Blood and Vessel Guidance 4
    III. Vascular and Neural Cell-Fate Specification 20
    IV. Molecular Links Between Angiogenesis and Neurogenesis 22
    V. Similarities in the Organization of Vascular and Neural Boundaries 24
    VI. Molecular Cues Involved in Nerve and Vessel Guidance 26
    VII. Perspectives 41
    Acknowledgments 42
    References 42
    2 Junction Restructuring and Spermatogenesis: The Biology， Regulation， and Implication in Male Contraceptive Development
    I. Introduction 58
    II. Anchoring Junctions in the Testes: An Update 60
    III. Roles of ECM Proteins in Junction Dynamics in the Testes 63
    IV. Role of Androgens in Junction Dynamics in Testes 72
    V. Regulation of Junction Turnover by Protein Endocytosis and Recycling 76
    VI. Regulation of Junction Dynamics by Myoid Cells 79
    VII. Environmental Toxicants: Are They Targeting the Tight and/or Anchoring Junction?
    VIII. Concluding Remarks 82
    Acknowledgments 83
    References 83
    3 Substrates of the Methionine Sulfoxide Reductase System and Their Physiological Relevance
    I. Introduction 94
    II. Regulated Substrates 96
    III. Scavenging Substrates 103
    IV. Modified Substrates with "Damaged" Effects 109
    V. Discussion 123
    References 125
    4 Organic Anion-Transporting Polypeptides at the Blood-Brain and Blood-Cerebrospinal Fluid Barriers
    I. Introduction 136
    II. BBB Structure and Function 136
    III. BCSFB Structure and Function 138
    IV. The OATP/Oatp Superfamily 140
    V. Molecular Architecture of the Oatp Superfamily 142
    VI. Oatp Substrate Structural Features 145
    VII. OATP/Oatp Expression and Action at the BBB and BCSFB 148
    VIII. Specific Oatps/Oatps Expressed at BBB and BCSFB 151
    IX. PG Metabolism and Oatps 155
    X. Oatp-Mediated Transport of Conjugated Endobiotics 158
    XI. Oxidation， Conjugation， and Transport Metabolism of DHEA and Estradiol (E2) in the Brain 159
    XII. Summary 163
    Acknowledgments 164
    References 164
    5 Mechanisms and Evolution of Environmental Responses in Caenorhabditis elegans
    I. Introduction 172
    II. Interactions Between Organism and Environment 173
    III. The Nematode C. elegans 176
    IV. Overview of C. elegans Responses to the Environment 180
    V. Phenotypic Plasticity of C elegans Dauer Formation 186
    VI. Environmental Robustness of C. elegans Vulva Formation 190
    VII. Conclusion 198
    Acknowledgments 198
    References 199
    6 Molluscan Shell Proteins: Primary Structure， Origin， and Evolution
    I. Introduction: The Shell， a Biologically Controlled Mineralization 210
    II. Molluscan Shell Formation: Developmental Aspects 212
    III. The Topographic Models of Shell Mineralization 221
    IV. Molluscan Shell Proteins: Characterization of Their Primary Structure 229
    V. Origin and Evolution of Molluscan Shell Proteins 254
    VI. Concluding Remarks 262
    Acknowledgments 263
    References 263
    7 Pathophysiology of the Blood-Brain Barrier: Animal Models and Methods
    I. The Blood Brain Barrier 278
    II. Animal-Based Methods in BBB Pathophysiology 285
    III. BBB Dysfunction as a Complication of Peripheral Disease 292
    IV. The BBB in Disease Etiology 295
    V. Concluding Remarks 297
    Acknowledgments 297
    References 297
    8 Genetic Manipulation of Megakaryocytes to Study Platelet Function
    I. Introduction 312
    II. Culture and Differentiation of Megakaryocytes 313
    III. Genetic Manipulation of Megakaryocytes 320
    IV. Current Use and Future Application of Megakaryocytes 325
    Acknowledgments 331
    References 332
    9 Genetics and Epigenetics of the Multifunctional Protein CTCF
    I. History of CTCF Discovery 338
    II. Multifunctional Nature of CTCF Versus Its Multiple Sequence Specificity 338
    III. CTCF Functions in Epigenetic Regulation in Development 344
    IV. CTCF Function in Chromatin Organization of Repetitive Elements 346
    V. Is CTCF a Tumor Suppressor Gene? 348
    VI. Concluding Remarks 353
    Acknowledgments 353
    References 354
    Index
    Contents of Previous Volumes 373