Immunological tolerance : methods and protocols / edited by Paul J. Fairchild. — Totowa : Humana Press, c2007.—(58.17/M592/v.380)

Contents

    Contents
    
    Preface
    Contributors
    1 Frontiers of Immunological Tolerance
    PART I CELL TYPES CONTRIBUTING TO IMMUNOLOGICAL TOLERANCE
    2 Balancing Tolerance and Immunity: The Role of Dendritic Cell and T Cell Subsets
    3 Differentiation of Dendritic Cell Subsets from Mouse Bone Marrow
    4 Genetic Modification of Dendritic Cells Through the Directed Differentiation of Embryonic Stem Cells
    5 Generation of lmmunocompetent T Cells from Embryonic Stem Cells
    6 Isolation， Expansion， and Characterization of Human Natural and Adaptive Regulatory T Cells
    7 Derivation， Culture， and Characterization of Thymic Epithelial Cell Lines
    PART II THE STUDY OF IMMUNOLOGICAL TOLERANCE IN VITRO
    8 Thymus Organogenesis and Development of the Thymic Stroma
    9 Generation of a Tissue-Engineered Thymic Organoid
    10 Studying T-Cell Repertoire Selection Using Fetal Thymus Organ Cultures
    11 Investigating Central Tolerance with Reaggregate Thymus Organ Cultures
    12 Estimating Thymic Function Through Quantification of T-Cell Receptor Excision Circles
    13 Gene Expression Profiling of Dendritic Cells by Microarray
    14 SAGE Analysis of Cell Types Involved in Tolerance Induction
    15 Analyzing the Physicodynamics of Immune Cells in a Three-Dimensional Collagen Matrix
    PART III THE STUDY OF IMMUNOLOGICAL TOLERANCE IN Vlvo
    16 Etiology of Autoimmune Disease: How T Cells Escape Self-Tolerance
    17 Animal Models of Spontaneous Autoimmune Disease: Type 1 Diabetes in the Nonobese Diabetic Mouse
    18 Antigen-Based Therapy and Immune Regulation in Experimental Autoimmune Encephalomyelitis
    19 Induction and Regulation of Inflammatory Bowel Disease in Immunodeficient Mice by Distinct CD4+ T-Cell Subsets
    20 In Vivo Models for the Study of Transplantation Tolerance
    21 Ectopic Transplantation of Tissues Under the Kidney Capsule
    22 Intravital Two-Photon Imaging of T-Cell Priming and Tolerance in the Lymph Node
    23 Tracing Tolerance and Immunity In Vivo by CFSE-Labeling of Administered Cells
    Part IV METHODS For AND BREAKING IMMUNOLOGICAL TOLERANCE
    24 Thymic Involution: Implications for Self-Tolerance
    25 Inducing Mixed Chimerism and Transplantation Tolerance Through AIIogeneic Bone Marrow Transplantation with Costimulation Blockade
    26 Induction of Dominant Tolerance Using Monoclonal Antibodies
    27 Induction of Tolerance by Adoptive Transfer of TregCells
    28 Modulation of the Immune Response Using Dendritic Cell-Derived Exosomes
    29 Breaking Self-Tolerance to Tumor-Associated Antigens by In Vivo Manipulation of Dendritic Cells