Advances in immunology. v. 91 / edited by Frederick W. Alt. — Amsterdam : Elsevier, 2006. -- (58.691/A244/v.91)

Contents

    Contents
    
    A Reappraisal of Humoral Immunity Based on Mechanisms of Antibody-Mediated Protection Against Intracellular Pathogens
    Abstract
    1. Introduction
    2. Intracellular and Extracellular Pathogenic Microbes: How Distinct Are They?
    3. Components of AMI
    4. AMI in the Context of the "Damage-Response Framework".
    5. Abs as Enhancers of Innate Immunity
    6. Abs as Direct and Indirect Effector Molecules
    7. AMI as a Regulator of the Inflammatory Response
    8. Dose-Response Conundrum
    9. Ab-Mediated Protection Against Intracellular Pathogens
    10. Protective Efficacy of an Ab Molecule
    11. Some Emerging Concepts
    References
    Accessibility Control of V(D)J Recombination
    Abstract
    1. Introduction
    2. V(D)J Recombination: A Mechanistic Perspective .
    3. Genomic Architecture of Ig and TCR Loci
    4. Regulation of Antigen Receptor Gene Assembly During Lymphocyte Development
    5. Regulation of V(D)J Recombination: The Accessibility Hypothesis and Beyond
    6. Chromatin Structure and Accessibility Control Mechanisms
    7. Regulation of Antigen Receptor Loci by Nuclear Topography
    8. Regulation of Chromatin Accessibility and V(D)J Recombination by Cis-Acting Elements
    9. Bole of Transcription in Accessibility Control of V(D)J Recombination
    10. Transcription Factors Involved in Accessibility Control of Ig and TCR Loci
    11. Control of Recombinase Accessibility by Chromatin Modifications and Remodeling
    12. Concluding Remarks
    References
    Targeting Integrin Structure and Function in Disease
    Abstract
    1. Introduction
    2. Structure， Ligand-Binding Sites， and Competitive Antagonists
    3. Large Conformational Changes and Affinity States
    4. I-Domain Allosteric Site and Antagonists
    5. An Internal Ligand
    6. βI-Domain Allosteric Regulation
    7. The PSI- and EGF-Domain Restraints
    8. The Cytoplasmic Domain Restraint
    9. Therapeutics
    10. Concluding Remarks
    References
    Endogenous TLR Ligands and Autoimmunity
    Abstract
    1. Introduction (Short Overview on TLR Immunobiology)
    2. The Innate: Adaptive Immune Connection
    3. TLR-Mediated Immunostimulatory Potential of Self-RNA and -DNA
    4. Function of IFN-α/β
    5. Cytokine-Driven DC Activation: A Portal for Autoimmunity?
    6. TLRs and Autoimmunity
    7. TLRs and "Innate Autoimmunity'
    References
    Genetic Analysis of Innate Immunity
    Abstract
    1. Introduction
    2. How Do We Detect Infection?
    3. Forward and Reverse Genetic Analyses of TLR Signaling
    4. TLR-Independent Detection of Microbes
    5. Global Resistome
    6. Endogenous Activators of TLR Signaling?
    7. Conclusions About Innate Immunity and the Classical Genetic Approach
    References
    TIM Family of Genes in Immunity and Tolerance
    Abstract
    1. Introduction
    2. TIM Family of Genes
    3. Tim-3 and Its Ligand Galectin-9 Inhibit Thl Responses
    4. Tim-2 and Its Ligands
    5. Tim-l， Th2 Cells， and Asthma
    6. Tim-4， a Natural Ligand for Tim-1
    7. TIM Molecules in Health and Disease
    8. TIM-l， Hepatitis A Virus Cellular Receptor， and Linkage to Human Asthma
    References 245
    Inhibition of Inflammatory Responses by Leukocyte Ig-Like Receptors
    Abstract 251
    1. Introduction
    2. LILRB1
    3. LILRB2
    4. LILRB3
    5. LILRB4
    6. LILRB5
    7. PIR-B
    8. Conclusions
    References
    Index
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