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Apoptosis and cancer therapy : from cutting-edge science to novel therapeutic concepts . v. 1 / edited by Klaus-Michael Debatin and Simone Fulda. — Weinheim : Wiley-VCH, c2006.—(64.86/A644/v. ) |
Contents
Contents
Volume 1
Preface
Part I Death Receptor
1 The role of CD95/CD95 Ligand Signaling in Apoptosis and Cancer 3
2 The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction， Therapeutic Potential for Cancer Treatment and Physiological Function 31
3 Mechanisms of Tumor Necrosis Factor-induced Cell Death 93
4 Cellular FLICE-inhibitory Protein: An Update 120
5 Dependence Receptors and Apoptosis 157
Part II Mitochondria
6 Role of Mitochondrial Proteins in Apoptosis 185
7 Omi/HtrA2: A Mitochondrial Serine Protease Regulating Cellular Life and Death 222
8 Apoptosis-inducing Factor 233
Part III Effector Systems
9 Caspases: Agents of Defense and Destruction 259
10 The Role of the Apoptosome in Apoptosis and Cancer Therapy 282
Part IV Bcl-2 Family
11 The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy 317
12 Bax， Bak and Bid: Key Mediators of Apoptosis 346
13 The BH3-only Proteins Puma and Noxa: Two Brothers in Arms 379
Part Ⅴ IAPs
14 Inhibitor of Apoptosis Proteins 405
15 Targeting the Survivin Pathway for Rational Cancer Therapy 427
Part VI Survival Pathways
16 Nuclear Factor-KB in Apoptosis and Tumorigenesis 445
17 Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B 462
18 Survival Regulation by Ras and Raf 490
Part VII Oncogenes/Tumor Suppressor Genes
19 p53-mediated Apoptosis: A Multifaceted Story 517
20 p73 Affects Cell Fate and Tumorigenesis 536
21 RB and Cancer 551
Part VIII Modulators
22 Calcium Signaling in Apoptosis 571
Part IX Lysosomes and Nonapoptotic Pathways
23 Lysosomes and Nonapoptotic Pathways 599
Part X Phagocytosis/Clearance
24 The Role of "Eat Me"， "Don't Eat Me" and "Find Me" Signals for the Efficient Removal of Apoptotic Cells 625
25 Apoptotic Cell Clearance by Macrophages: Relevance to Tumor Pathogenesis 647
Volume 2
Part Ⅺ Model Systems
26 Mouse Models in Cancer Research 671
Part Ⅻ Molecular Diagnosis
27 Molecular Imaging in Cancer 705
28 Microarray-based Expression Profiling: From Technological Basics to Diagnostic Perspectives 728
Part XIII Cellular Stress， DNA Damage and Repair
29 Life and Death Decisions in Response to Stress 757
30 Hypoxia in Cancer 777
31 Apoptosis Induced by DNA-damaging Agents 799
32 DNA Repair 822
Part XIV Molecular Targets and Therapeutics
33 Therapeutic Modulation of Apoptosis in Cancer Therapy 849
34 Current Therapeutic Strategies Targeting Caspases in Disease 862
35 Cancer Therapy by Reactivation of the pS3 Apoptosis Pathway 891
36 Small-molecule Inhibitors of the Inhibitor of Apoptosis Proteins 913
37 Inhibition of the Molecular Chaperone Heat Shock Protein 90 in Cancer: Consequences for the Regulation of Survival Signaling and Induction of Cell Death 933
38 Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway 966
39 Ceramide Signaling in Apoptosis and Cancer Therapy 997
40 Histone Deacetylase Inhibitors: Development as Anticancer Agents 1014
41 Exploiting Apoptosis Pathways for Glioblastoma Therapy 1033
42 Radiation Therapy and Apoptosis 1049
43 Tumor Angiogenesis 1087
Index 1107
