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Amyloid proteins : the beta sheet conformation and disease / edited by Jean D. Sipe. —Weinheim : Wiley-VCH, c2005.—(63.8516/A531/v. ) |
Contents
Contents
Volume 1
Part Ⅰ Overview of Amyloidosis and Amyloid Proteins
1 Amyloidosis and Amyloid Proteins: Brief History and Definitions 3
2 Anatomic and Clinical Clues to In Vivo Mechanisms of Amyloidogenesis 29
Part Ⅱ Protein Structure and the Beta Pleated Sheet Conformation
3 The β-pleated Sheet Conformation and Protein Folding: A Brief History 49
Part Ⅲ Protein Folding， Unfolding and Refolding
4 Thermodynamics and Protein Folding 65
5 Role of Post-translational Chemical Modifications in Amyloid Fibril Formation 81
6 Lipid Modulators of Protein Misfolding and Aggregation 111
7 Extracellular Matrix Heparan Sulfate Proteoglycans 131
8 Serum Amyloid P Component 169
9 Serum amyloid P Component -Structural Features and Amyloid Recognition 189
10 Apolipoprotein E: Structural and Functional Interactions with Amyloid β 211
Part IV Pathway to Amyloid Fibril Formation
11 Pathways to Amyloid Fibril Formation: Partially Folded Intermediates in the Fibrillation of Natively Unfolded Proteins 247
12 Structural Intermediates of Globular Proteins as Precursors to Amyloid Formation 275
13 Computational Approaches and Tools for Establishing Structural Models for Short Amyloid-forming Peptides 301
Part Ⅴ Pathophysiology of Amyloid Fibril Formation
14 Oligomers and Cellular Toxicity 319
15 The Future of Molecular Diagnostics and Targeted Therapeutics in the Amyloidoses 343
16 Brain Dysfunction Associated with Amyloid Fibrils and Other Aggregated Proteins 355
Volume 2
Part VI Amyloid Proteins
Brain 385
17 The Amyloid β Protein 385
18 Prion Protein 493
19 Familial British and Danish Dementias 515
Systemic 527
20 Immunoglobulin 527
21 Transthyretin 571
22 High-Density Lipoprotein Amyloid Proteins 589
23 Gelsolin 625
24 Lysozyme 635
25 Fibrinogen 657
26 β2-Microglobulin 667
27 Cystatin C 697
Hormone 723
28 Endocrine Amyloid 723
Glossary of Terms 755
Subject Index 759
