1.       Structure and stability of the α-helix: lessons for design  3

2.       De novo design of monomeric β-Hairpin and β-Sheet petides  27

3.       De novo proteins from binary-patterned combinatoryial libraryies  53

4.       Non-protein amino acids in the design of secondary structure scaffolds  71

5.       Design and synethesis of β-peptides with biological activity  95

6.       Design of miniproteins by the transfer of active sites onto small-size scaffolds  113

7.       Consensus design as atool for engineering repeat proteins  151

8.       Multiple sequence alignment as a guideline for protein engineering strategies  171

9.       Sequence search methods and scoring functions for the design of protein structures  183

10.   Prediction of protein-protein interaction based on structure  207

11.   Electrostatic design of protein-protein association rates  235

12.   Peptide model systems for amyloid fiber formation: design strategies and validation methods  253

13.   Protein misfolding disorders and rational design of antimisfolding agents  277