Pharmaceutical biotechnology : drug discovery and clinical applications / by Oliver Kayser, Rainer H. M"uller. -- Wiley-VCH, 2004. -- (63.3034/K23)

Contents:

1. a Primer on Pharmaceutical biotechnology and Industrial Applications  3

2. Procaryotic and Eucaryotic Cells in biotech Production  9

3. Biopharmaceuticals Expressed in Plants  35

4. Scientific, Technical and Economic Aspects of Vaccine Research and Development  59

5. DNA Vaccines: from Research Tools in Mice to Vaccines for Humans  79

6. Characterization and bioanalytical Aspects of Recombinant Proteins as Pharmaceutical Drugs  103

7. Biogeneric Drugs  119

8. Pharmacokinetics and Pharmacodynamics of Biotech Drugs   147

9. Formulation of Biotech Products  173

10. Patents in the Pharmaceutical Biotechnology Induystry: Legal and Ethical Issues  187

11. Drug Approval in the European Union and the United States  201

12. Ritucimab: Clinical Development of the First Therapeutic Antibody for Cancer  213

13. Somatic Gene Therapy - Advanced Biotechnology Products in clinical Development  231

14. Nonviral Gene Transfer Systems in Somatic Gene Therapy  249

15. Xenotransplanation in Pharmaceutical Biotechnology  265

16. Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices  281