Molecular biology in medicinal chemistry / edited by Th. Dingermann ... [et al.]. -- Wiley-VCH, 2004. -- 63.32/M718

Contents

Contents:

1. Cellular Assays in Drug Discovery  3

2. Gene Knockout Models  48

3. Reporter Gene Systems fot the Investigation of G-protein-coupled Receptors  73

4. From the Human Genome to New Drugs: The Potential of Orphan G-proteincoupled Receptors  95

5. Steroselective Synthesis with the Help of Recombinant Enzymes  125

6. Nucleic Acid Drugs  153

7. Recent Trends in Enantioseparation of Chiral Drugs  181

8. Affinity Chromatography  211

9. Nuclear Magnetic Resonance-based Drug Discovery  242

10. (13)C-and (15)N-Isotopic Labeling of Proteins  269

11. Application of antibody Fragments as Crystallization Enhancers  300

12. Pharmacogenetics: the Effect of Inherited Genetic Variation on Drug Disposition and Drug Response  325

13. Pharmacogenomics of Bioavailability and Elimination  363

14. Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology  381