Molecular analysis and genome discovery / edited by Ralph Rapley and Stuart Harbron. -- John Wiley & Sons. -- 2004. -- 58.1481/M718g

Contents

Contents:

1. Pharmacogenetics and Pharmacogenomics: An Overview  1

2. Quantitative TaqMan Real-time PCR: Diagnostic and Scientific Applications  17

3. Hybridization Probes for Real-time PCR  29

4. An Overview of Genotyping and Single Nucleotide Polymorphisms (SNP)  43

5. High-throughput Mutation Screening  71

6. Determination of Nucleic Acid Sequences by Pyrosequencing  101

7. An Introduction to DNA Chips  113

8. Overview of Microarrays in Genomic Analysis  127

9. Overview of Differential Gene Expression by High-throughput Analysis  167

10. Aptamers: Powerful Molecular Tools for Therapeutics and Diagnostics  191

11. Chip-based Proteomics Technology  217

12. Indectomics Overview: Holistic and Integrativs Studies of Infectious Diseases  251

13.The Drug Discover Process  271

14. Structure-based Drug Discovery  295

15. Protein Interaction-targeted Drug Discovery  323

16. Overview of Quantitative Structure-Activity Relationships (QSAR)  347