Case studies in cell biology / Merri Lynn Casem. -- London : Academic Press is an imprint of Elsevier, 2016. – (58.15 /C337) |
Contents
BIOGRAPHY xvii
PREFACE xix
CHAPTER
1 Introduction to scientific method
from a cellular perspective 1
Subchapter
1.1 Scientific method in action 1
CHAPTER
2 Cellular biodiversity 11
Subchapter
2.1 Cellular biodiversity on the high seas
11
Subchapter
2.2 The mystery of the missing mitochondria
17
CHAPTER
3 Proteins 23
Subchapter
3.1 Bite of the brown recluse spider: an introduction to protein gel
electrophoresis 23
Subchapter
3.2 Where to start? a case of too many AUGs
31
Subchapter
3.3 Cotranslational translocation: gatekeepers of the RER 39
Subchapter
3.4 From sequence to function 47
Subchapter
3.5 Visualizing protein conformation 54
Subchapter
3.6 Second chance chaperones: how misfolded proteins get refolded 62
CHAPTER
4 The nucleus
Subchapter
4.1 Nuclear pore complex assembly is a house of cards 73
Subchapter
4.2 Importin β:
the important importin 80
Subchapter
4.3 A tale of tRNA transport 88
Subchapter
4.4 When it comes to the nucleus - size matters
96
CHAPTER
5 Membranes and membrane
transport 105
Subchapter
5.1 Flip this lipid 105
Subchapter
5.2 Navigating the bilayer: lipid rafts and caveolae 113
Subchapter
5.3 Shifting gears" calcium transport in flagella 120
CHAPTER
6 Cytoskeleton and intracellular
motility 127
Subchapter
6.1 Plakins: keeping the cytoskeleton safe
127
Subchapter
6.2 The moving story of a microtubule motor protein 134
Subchapter
6.3 The WASP and the barbed end 142
Subchapter
6.4 Cilia grow where vesicles go 150
CHAPTER
7 Organelles 157
Subchapter
7.1 Putting the "retic" in the endoplasmic reticulum 157
Subchapter
7.2 How the Golgi stacks up 164
Subchapter
7.3 Case of the coated vesicle 172
Subchapter
7.4 How to build a peroxisome 180
Subchapter
7.5 Putting the squeeze on mitochondAa
187
CHAPTER
8 Exocytosis 193
Subchapter
8.1 Coat proteins and vesicle transport
193
Subchapter
8.2 Endomembrane transport in the absence of a cell 202
Subchapter
8.3 Extra large export: a case for cisternal maturation 209
CHAPTER
9 Endocytosis 217
Subchapter
9.1 Following the fate of a phagosome
217
Subchapter
9.2 Catching a receptor by the tail 224
Subchapter
9.3 Can clathrin bend a membrane? 229
Subchapter
9.4 Modeling membrane fission 235
CHAPTER
10 Cell walls and cell adhesion 241
Subchapter
10.1 Biofilms and Antibiotic Resistance
241
Subchapter
10.2 DIY ECM: cortactin and the secretion of fibronectin 246
Subchapter
10.3 Bundling the brush border 253
CHAPTER
11 Cell
metabolism 263
Subchapter
11.1 When glucose is low, something must go
263
Subchapter
11.2 Do plants really need two photosystems?
270
Subchapter
11.3 FREX: opening a window into cellular metabolism 275
CHAPTER
12 Cell signaling
283
Subchapter
12.1 How cells know when it's time to go
283
Subchapter
12.2 Can you "Ad" hear me now? signaling and intraflagellar
transport 290
CHAPTER
13 Cell cycle
299
Subchapter
13.1 Now you see it, now you don't: the discovery of cyclin 299
Subchapter
13.2 Sorting out cyclins 305
Subchapter
13.2 Of centriole separation and cyclins
312
Subchapter
13.4 The path to S phase is paved with phosphorylation 319
CHAPTER
14 Cell division
327
Subchapter
14.1 Push and pull: how motor proteins help build a spindle 327
Subchapter
14.2 Ready, set, anaphase! 333
Subchapter
14.3 Building cell walls: cytokinesis in a plant cell 338
CHAPTER
15 Cell systems
345
Subchapter
15.1 Do bumblebees have B cells? a case of insect immunity 345
Subchapter
15.2 What happens when the endosymbionts "bug out"? 353
Subchapter
15.3 Parvovirus: hijacking endocytosis
362
SUBJECT INDEX 373