Advances in protein chemistry and structural biology. Volume 101 / edited by Rossen Donev. -- Amsterdam : Academic Press, 2015. – (58.17421/A244p/v.101)

Contents

Contributors

1. The Eukaryotic Translation Initiation Factor 4E (elF4E) as a Therapeutic Target for Cancer

1. Introduction

2. elF4E's Structure and Expression

3. elF4E's Functions

4. eIF4E: A Therapeutic Target in Cancer

5. Conclusion

References

2. Antitumor LipidsmStructure, Functions, and Medical Applications

1. introduction

2. Development of Antitumor Lipids

3. Combining ATLs with Other Anticancer Approaches

4. Structure of Antitumor Lipids

5. Clinical Trials and Therapeutic Effect

6. Anticancer Mechanism of Action

7. Conclusion and Perspectives

Acknowledgments

References

3. Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane

1. Telomeres

2. Telomeres Protect Ends of Chromosomes

3. Shelterin: The Telomere-Specific Protein Complex

4. Telomeres Take Part in Chromatin Organization

5. Structure of the Telomere-Binding Protein TRF2

6. TRF2 is Tightly Bound to the NE

Acknowledgments

References

4. Alterations in Gene Expression in Depression: Prospects for Personalize Patient Treatment

1. Introduction

2. Etiology of Depression--A Brief Summary

3. Mechanisms of Action of Antidepressant Treatments

4. Altering Gene Expression Levels in Depression

5. Profiling Expression Pattern of Depression-Related Genes as a Too for Correct Diagnosing and Personalized Patient Treatment

6. Concluding Remarks

References

5. Evolution and Coevolution of PRC2 Genes in Vertebrates and Mammals

1. Introduction

2. Results

3. Discussion

4. Methods

Acknowledgment

References

6. Quartz-Crystal Microbalance (QCM) for Public Health: An Overview of Its Applications

1. Introduction

2. Biosensors and Nanosensors

3. Quartz-Crystal Microbalance

4. Bacteria and QCM: A New Strategy for Detecting Microbial Population

5. QCM and Nosocomial Infections

6. Bacteria and QCM: Role in Monitoring Antimicrobial Susceptibility and Drug Resistance

7. Influenza Virus and Other Respiratory Viruses

8. Sexually Transmitted Diseases

9. Invasive Diseases

10. Tropical and Tropical Neglected Diseases

11. Cancer

12. Chronic Degenerative Diseases

13. Occupational Hygiene

14. Water Safety

15. Veterinary Public Health

16. Food Hygiene

17. Environmental Monitoring

18. Biohazards and Bioterrorism

19. Homeland Security

20. Concluding Remarks

References

7.  Porous Alumina as a Promising Biomaterial for Public Health

1. Introduction

2. Porous Alumina for Microbiology: From Germ Culture to High-Throughout Microbiology

3. Porous Alumina-Based Biosensors for Pathogen Detection

4. Porous Alumina ant its Antimicrobial Properties

5. Food Production and Manipulation

6. Food Safety Assurance

7. Water Safety Assurance

8. Environmental Monitoring

9. Concluding Remarks

References

8.  Human Papillomavirus Vaccine: State of the Art and Future Perspectives

1. Human Papillomavirus

2. Genome

3. Proteome

4. L1 Protein

5. L2 Protein

6. E1 Protein

7. E2 Protein

8. E3 Protein

9. E4 Protein

10. E50ncoprotein

11. E60ncoprotein

12. E70ncoprotein

13. E8/E8^E2C Protein

14. HPV Life Cycle

15. An Overview of the Current Technologies Used for Vaccines Production

16. Virus-Like Particles Based Vaccines

17. Plant-Based Vaccines

18. Recombinant-Based Vaccines

19. Prophylactic and Therapeutic Vaccines

20. Currently Available Prophylactic Vaccines

21. Future Generation Prophylactic Vaccines

22. Therapeutic Vaccines

23. Further Combined Strategies

24. Conclusions

References

9. SHOPIN: Semantic Homogeneity Optimization in Protein Interaction Networks

1. Introduction

2. Materials and Methods

3. Results and Discussion

4. Conclusions

References

Author Index

Subject Index