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Brain stimulation : methodologies and interventions / edited by Irving M. Reti. -- Hoboken, New Jersey : Wiley Blackwell, c2015. – (59.597/B814b)

Contents

Contributors

1  Introduction to Brain Stimulation

Introduction

A Historical Perspective

Focal Activation

Connectivity

Development of Invasive Brain Stimulation

Ethical Issues

References

Part A  brain circuitry and plasticity

2  A Balanced Mind: A Network Perspective on Mood and Motivation Brain Pathways

Introduction

Dysregulation of Emotion and Mood

Potential for Intervention

Conclusion

References

3  Motor Pathways, Basal Ganglia Physiology, and Pathophysiology

Introduction

The Classic Models of Basal Ganglia Anatomy

Basal Ganglia Physiology

The Pathophysiology of Hypo- and Hyper Dopaminergic States

From Physiology to Understanding and Therapy--the Computational Models of the Basal

Ganglia

References

4  Viewing Brain Stimulation from a Plasticity Perspective

Long-Term Potentiation: A Primer

AMPA Versus NMDA Receptors

Distinct Mechanisms of LTP Induction and Expression

Synapse Specificity of LTP

Relevance of LTP Mechanisms to Mode of Action of tDCS

Long-Term Depression

Metaplasticity and Monoamines

Clues to rTMS Mode of Action

Future Directions

Summary

References

Part B Technology

(l) Non-Invasive Brain Stimulation Modalities

(a) Convulsive

5  Introduction to Convulsive Therapy

Introduction

The History of Convulsive Therapy

Electroconvulsive Therapy: Basic Principles

Electroconvulsive Therapy: Clinical Role

Magnetic Seizure Therapy (MST)

Focal Electrically Administered Seizure Therapy (FEAST)

Future of Convulsive Therapy

References

6  Improving ECT Efficacy and Decreasing Cognitive Side Effects

Keith G. Rasmussen

Introduction

ECT Outcome Assessment: Therapeutic Efficacy and Cognitive Side Effects

ECT Treatment Technique: Basic Concepts

Electrode Placement

Stimulus Dosage

Stimulus Parameter Configuration

Treatment Frequency

Concomitant Psychotropic Drugs

Choice of Anesthetic Drug

References

7  How Does Electroconvulsive Therapy Work?

Introduction

What Can We Learn from ECT's Action as an Antidepressant?

What Can We Learn from ECT's Action in Treating Catatonia?

How Do Stimulus Parameters that Trigger the Seizure Influence How It Works?

Conclusions and Implications for ECT Treatment

References

8  Magnetic Seizure Therapy for the Treatment of Depression

Introduction

Definitions

Rationale for MST

History of MST: A Translational Developmental Trajectory

MST Technique

E-field Distribution with MST

Neurophysiological Effects of MST

Safety

Antidepressant Efficacy

Future Directions for MST Development

Conclusions

References

(b) Non-Convulsive

9  Introduction to Nonconvulsive Brain Stimulation: Focus on Transcranial Magnetic Stimulation

History of Nonconvulsive Transcranial Brain Stimulation Technique in Humans

Basics of Transcranial Magnetic Stimulation

New Techniques: Static Magnets and Pulsed Ultrasound

References

10 Advances in Transcranial Magnetic Stimulation Technology

Introduction

Pulse Source Technology and Waveforms

Coils

Technical Aspects of Concurrent TMS and Neuroimaging

Conclusion and Future Directions

References

11 Applications of TMS to Study Brain Connectivity

Introduction

Probing Connectivity using Bifocal TMS

Connectivity Studies Using TMS Plus fMRI, PET or EEG

Conclusions

References

12 Therapeutic Applications of rTMS for Psychiatric and Neurological Conditions

Introduction

The Depressions

The Anxiety Disorders

The Schizophrenias

Pain Syndromes

Movement Disorders

Repairing the Damaged Brain

Other Conditions

Summary and Conclusions

References

13 Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

Introduction

Physiological Basis of tDCS

Impact of tDCS on Cognition

Application of tDCS in Neuropsychiatric Diseases

Concluding Remarks

References

(2) Invasive Brain Stimulation Modalities

14 Epidural Cortical Stimulation

Introduction

Options for Treatment Resistant Depression

Epidural Cortical Stimulation

Disrupted Emotion Regulation in Depression and EpCS

Deficits in Mentalization in Depression and EpCS

Comparison Across Brain Stimulation Therapies

Summary

References

15 Neurological Indications for Deep Brain Stimulation

Introduction

Current Indications for Deep Brain Stimulation

Safety of Deep Brain Stimulation

Fundamentals of Stimulation

Lead Placement

Conclusion

References

16 Psychiatric Indications for Deep Brain Stimulation

Introduction

Deep Brain Stimulation and Obsessive Compulsive Disorder

Deep Brain Stimulation and Major Depressive Disorder

Deep Brain Stimulation and Drug Addiction

Potential New Indications for Deep Brain Stimulation

References

17 Vagus Nerve Stimulation for Epilepsy and Depression

Introduction

The VNS Therapy Device

Vagus Nerve Anatomy

Mechanisms of Action of VNS

Epilepsy

Depression

General Safety Considerations

Future Directions

Summary

References

Index