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Bioactive natural products : chemistry and biology / edited by Goutam Brahmachari. -- Weinheim : Wiley-VCH, c2015. – (54.56/B615) |
Contents
Contents
Foreword VII
Preface XXI
About the Editor XXV
List of Contributors XXVI
1 An Overview 1
2 Use of Chemical Genomics to Investigate the Mechanism of Action for inhibitory Bioactive Natural Compounds 9
2.1 Introduction: Antibiotic Resistance and the Use of Natural Products as a Source for Novel Antimicrobials 9
2.2 Chemical Genetics and Genomics 10
2.3 Development of GDA Technology 11
2.4 Concluding Remarks 22
Abbreviations 24
References 24
3 High-Throughput Drug Screening Based on Cancer Signaling in Natural Product Screening 33
3.1 Introduction 33
3.2 Cancer Signaling Pathways with Their Own Drug Screening Assays in HTS 35
3.3 Concluding Remarks 37
Abbreviations 38
References 38
4 Immunosuppressants: Remarkable Microbial Products 43
4.1 Introduction 43
4.2 Discovery 44
4.3 Mode of Action 47
4.4 Biosynthesis 49
4.5 Genetics and Strain Improvement 63
4.6 Fermentation and Nutritional Studies 65
4.7 Other Activities of lmmunosuppressants 69
4.8 Concluding Remarks 71
Acknowledgments 72
References 72
5 Activators and Inhibitors of ADAM-10 for Management of Cancer and Alzheimer's Disease 83
5.1 Introduction to ADAM Family of Enzymes 83
5.2 ADAM-10 Structure and Physiological Roles 85
5.3 Pathological Significance 85
5.4 ADAM-10 as Potential Drug Target 87
5.5 Synthetic Inhibitors of ADAM-10 88
5.6 Natural Products as Activators and Inhibitors for ADAM-10 92
5.7 Natural Products as ADAM-10 Activators 93
5.8 Natural Products as ADAM-10 Inhibitors 96
5.9 Concluding Remarks 99
Abbreviations 99
References 99
6 Structure and Biological Activity of Polyether Ionophores and Their Semisynthetic Derivatives 107
6.1 Introduction 107
6.2 Structures of Polyether Ionophores and Their Derivatives 108
6.3 Chemical Properties of Polyether Ionophores and Their Derivatives 130
6.4 Biological Activity 133
6.5 Concluding Remarks 1，53
Abbreviations 1，54
References 1_，5，5
7 Bioactive Flavaglines: Synthesis and Pharmacology 171
7.1 Introduction 171
7.2 Biosynthetic Aspects 172
7.3 Synthesis of Flavaglines 174
7.4 Pharmacological Properties of Flavaglines 184
7.5 Structure-Activity Relationships (SARs) 192
7.6 Concluding Remarks 192
Abbreviations 193
References 194
8 Beneficial Effect of Naturally Occurring Antioxidants against Oxidative Stress-Mediated Organ Dysfunctions 199
8.1 Introduction 199
8.2 Oxidative Stress and Antioxidants 200
8.3 Concluding Remarks 227
Abbreviations 227
References 228
9 Isoquinoline Alkaloids and Their Analogs: Nucleic Acid and Protein Binding Aspects， and Therapeutic Potential for Drug Design 241
9.1 Introduction 241
9.2 Isoquinoline Alkaloids and Their Analogs 243
9.3 Concluding Remarks 267
Acknowledgments 268
Abbreviations 268
References 269
10 The Potential of Peptides and Depsipeptides from Terrestrial and Marine Organisms in the Fight against Human Protozoan Diseases 279
10.1 Introduction 279
10.2 Antiprotozoan Peptides and Depsipeptides of Natural Origin and Their Synthetic Analogs 281
10.3 Concluding Remarks 306
Abbreviations 307
References 307
11 Sesquiterpene Lactones: A Versatile Class of Structurally Diverse Natural Products and Their Sernisynthetic Analogs as Potential Anticancer Agents 321
11.1 Introduction: Structural Features and Natural Distribution 321
11.2 Anticancer Activity of Sesquiterpenes Lactones 323
11.3 Structure-Activity Relationships (SARs) of Sesquiterpenes Lactones 340
11.4 Concluding Remarks 341
Acknowledgments 342
Abbreviations 342
References 342
12 Naturally Occurring Calanolides: Chemistry and Biology 349
12.1 introduction 349
12.2 Naturally Occurring Calanolides: Structures and Physical Properties 350
12.3 Anti-HIV and Antituberculosis Potential of Calanolides 350
12.4 Total Syntheses of Calanolides 360
12.5 Concluding Remarks 369
Acknowledgment and Disclosure 370
Abbreviations 370
References 371
13 Selective Estrogen Receptor Modulators (SERMs) from Plants 375
13.1 Introduction 375
13.2 Structure of Estrogen Receptor 376
13.3 Estrogen Receptor Signaling 377
13.4 Selective Estrogen Receptor Modulators from Plants 379
13.5 Molecular Basis of the Distinct SERM Action 381
13.6 SERMs in the Treatment of Estrogen-Mediated Cancers 383
13.7 Concluding Remarks 383
Abbreviations 384
References 384
14 Introduction to the Biosynthesis and Biological Activities of Phenylpropanoids
14.1 Introduction 387
14.2 Biosynthesis of Phenylpropanoids 387
14.3 Some Phenylpropanoid Subclasses 392
14.4 Concluding Remarks 400
Acknowledgments 400
Abbreviations 400
References 401
15 Neuropeptides: Active Neuromodulators Involved in the Pathophysiology of Suicidal Behavior and Major Affective Disorders 409
15.1 Introduction 409
15.2 Methods 410
15.3 Involvement of Neuropeptides in the Pathophysiology of Suicidal Behavior and Major Affective Disorders 411
15.4 The Association between Neuropeptides， Suicidality， and Major Affective Disorders 426
15.5 Discussion of the Main Findings 429
15.6 Concluding Remarks 431
Abbreviations 432
References 433
16 From Marine Organism to Potential Drug: Using Innovative Techniques to Identify and Characterize Novel Compounds - a Bottom-Up Approach 443
16.1 Introduction 443
16.2 Structural Screening Approach 443
16.3 Testing for Bioactivity by Screening in Mammalian Cells 452
16.4 Chemical Genetics and Network Pharmacology in Yeast for Target Identification
16.5 Identification of Protein Targets by Proteomic Analysis on 2D Gels 462
16.6 Validation of Compound Targets by Biochemical Analysis 462
16.7 Next Steps in Drug Development 464
16.8 Concluding Remarks 466
Acknowledgments 467
Abbreviations 467
References 467
17 Marine Natural Products: Biodiscovery， Biodiversity， and Bioproduction 473
17.1 Introduction 473
17.2 Biodiscovery: What and Where? 474
17.3 Biodiversity 481
17.4 From Biodiscovery to Bioproduction 484
17.5 Concluding Remarks 486
References 487
Index 491
