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Targeted therapies in oncology / edited by Giuseppe Giaccone, Jean-Charles Soria. -- 2nd ed. -- Boca Raton : CRC Press, c2014. – (64.86 /T185 /2nd ed.)

Contents

    CONTENTS
    
    Role of Next-Generation Sequencing Technologies
    Siddhartha Devarakonda, Daniel Morgensztern, and Ramaswamy Govindan
    Signal Transduction Inhibitors of the HER Family
    Christina Brzezniak, Corey Carter, Anish Thomas, and Giuseppe Giaccone
    HER2 Inhibition and Clinical Achievements
    Berta Sousa, J. Ribeiro, and Fatima Cardoso
    Inhibiting the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway
    Simona Wagner and Janet E. Dancey
    BRAF and MEK Inhibitors
    Lidia Robert and Antoni Ribas
    KIT and KIT Inhibitors
    Jean-Yves Blay, Armelle Dufresne, Olfa Derbel, and Isabelle Ray-Coquard
    Targeting the Fibroblast Growth Factor Receptor Pathway in Human Cancer
    Maria Vittoria Dieci and Fabrice Andre
    Anaplastic Lymphoma Kinase
    Aparna Rao and Benjamin Solomon
    MET Inhibitors
    Apoorva Chawla, Ravi Salgia, and Victoria M. Villaflor
    Targeting Stem Cells
    Marcello Maugeri-Sacca and Ruggero De Maria
    The Cancer Super-Chaperone Hsp90: Its Posttranslational Regulation and Drug Targeting
    Annerleim Walton-Diaz, Sahar Khan, Jane B. Trepel, Mehdi Mollapour, and Len Neckers
    Targeting Apoptosis Pathways
    Pamela M. Holland, David Reese, and Jeffrey Wiezorek
    Targeting Angiogenesis
    Sophie Postel-Vinay and Jean-Pierre Armand
    Antivascular Agents
    Gianluca Del Conte and Cristiana Sessa
    Immunotherapy: Monoclonal Antibodies (CTLA4, PD-1, PD-L1, IL-18, and IL-21)
    Patrick M. Forde and Julie R. Brahmer
    Vaccine Therapy and Integration with Other Modalities
    Benedetto Farsaci, Peter S. Kim, James W. Hodge, Claudia Palena, James L. Gulley, and Jeffrey Schlom
    Histone Deacetylase Inhibitors as Targeted Therapies
    Alexandra Zimmer, Arup Chakraborty, Robert W. Robey, and Susan E. Bates
    Compounds Targeting Androgen Pathways
    Aurelius Omlin, Carmel Pezaro, and Johann de Bono
    Targeting DNA Repair: PARP and Chk1 Inhibitors
    Peter Stephens and Ruth Plummer
    Inhibitors Targeting Mitosis
    Dan L. Sackett, Edina Komlodi-Pasztor, and Tito Fojo
    Index