Essential developmental biology / Jonathan M.W. Slack. -- 3rd ed. -- Oxford : Wiley-Blackwell, 2013. – (58.13/S631/3rd ed.)

Contents

    CONTENTS
    
    Preface， ix
    About the companion website， xii
    Section I: Groundwork， 1
    I The excitement of developmental biology， 3
    Where the subject came from， 3
    Impact of developmental biology， 4
    Future impact， 4
    Further reading， 5
    2 How development works， 7
    Ultrashort summary， 7
    Gametogenesis， 10
    Early development， 12
    Morphogenetic processes， 19
    Growth and death， 23
    Further reading， 25
    3 Approaches to development: developmental genetics， 27
    Developmental mutants， 27
    Sex chromosomes， 29
    Maternal and zygotic， 29
    Genetic pathways， 29
    Genetic mosaics， 32
    Screening for mutants， 33
    Cloning of genes， 34
    Gain- and loss-of-function experiments， 34
    Gene duplication， 38
    Limitations of developmental genetics， 39
    Further reading， 40
    4 Approaches to development: experimental embryology， 42
    Normal development， 42
    Developmental commitment， 45
    Criteria for proof， 51
    Further reading， 52
    5 Approaches to development: cell and molecular biology techniques， 54
    Microscopy， 54
    Study of gene expression by molecular biology methods， 58
    Study of gene expression by in situ methods， 61
    Microinjection， 65
    Cell-labeling methods， 66
    Further reading， 68
    Section 2: Major model organisms， 71
    6 Model organisms， 73
    The big six， 73
    Access and micromanipulation， 75
    Genetics and genome maps， 75
    Relevance and tempo， 76
    Other organisms， 76
    Further reading， 78
    7 Xenopus ， 80
    Oogenesis， maturation， and fertilization， 80
    Normal development， 82
    Experimental methods， 87
    Processes of regional specification， 92
    Inductive interactions， 95
    Further reading， 104
    8 The zebrafish， 106
    Normal development， 106
    Genetics， 110
    Embryological and molecular techniques， 114
    Regional specification， 115
    Other uses for the zebrafish， 118
    Further reading， 120
    9 The chick， 121
    Normal development， 122
    Regional specification of the early embryo， 127
    Description of organogenesis in the chick， 133
    Further reading， 140
    10 The mouse， 141
    Mammalian fertilization， 141
    Normal development， 145
    Regional specification， 153
    Human early development， 158
    Mouse developmental genetics， 159
    Other topics in mouse development， 164
    Further reading， 169 11 Drosophila ， 171
    Insects， 171
    Normal development， 173
    Drosophila developmental genetics， 178
    The developmental program， 181
    Further reading， 197
    12 Caenorhabditis elegans ， 198
    Adult anatomy， 198 Embryonic development， 200
    Analysis of postembryonic development， 208
    Further reading， 215
    Section 3: Organogenesis， 217
    13 Techniques for studying organogenesis and postnatal development， 219
    Genetics， 219
    Clonal analysis， 223
    Tissue and organ culture， 226
    Cell separation methods， 228
    Further reading， 230
    14 Development of the nervous system， 231
    Overall structure and cell types， 231
    Anteroposterior patterning of the neural plate， 234
    Dorsoventral patterning of the neural tube， 238
    Neurogenesis and gliogenesis， 240
    The neural crest， 246
    Development of neuronal connectivity， 250
    Further reading， 257
    15 Development of mesodermal organs， 259
    Somitogenesis and myogenesis， 259
    The kidney， 266
    Germ cell and gonadal development， 269
    Limb development， 274
    Blood and blood vessels， 284
    The heart， 287
    Further reading， 293
    16 Development of endodermal organs， 296
    Normal development， 296
    Experimental analysis of endoderm development， 301
    The pancreas， 307
    Further reading， 312
    17 Drosophila imaginal discs， 314
    Metamorphosis， 314
    Disc development， 318
    Further reading， 328
    Section 4: Growth， regeneration， evolution， 331
    18 Tissue organization and stem cells， 333
    Types of tissue， 333
    Tissue renewal， 336
    Stem cells， 339
    Further reading， 360
    19 Growth， aging and cancer， 362
    Growth: control of size and proportion， 362
    Aging， 371
    Cancer， 374
    Further reading， 382
    20 Regeneration of missing parts， 384
    Distribution of regenerative capacity， 384
    Planarian regeneration， 385
    Insect limb regeneration， 388
    Vertebrate limb regeneration， 390
    General properties of regeneration， 399
    Further reading， 400
    21 Applications of pluripotent stem cells， 401
    Cell transplantation therapy， 401
    Embryonic stem cells， 403
    Personalized pluripotent stem cells， 406
    Proposed cell transplantation therapies using pluripotent stem cells， 411
    Further reading， 417
    22 Evolution and development， 419
    Macroevolution， 420
    The primordial animal， 424
    What really happened in evolution?， 429
    Further reading， 438
    Appendix: Key molecular components， 440
    Genes， 440
    Transcription factor families， 442
    Signaling systems， 443
    Inducing factor families， 445
    Cytoskeleton， 449
    Cell adhesion molecules， 451
    Extracellular matrix components， 452
    Further Reading， 452
    Glossary， 454
    Index， 467