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Progress in molecular biology and translational science. Volume 102, Cellular RNA interference mechanisms / edited by Dirk Grimm. -- Amsterdam ; Boston : Elsevier Academic Press,, c2011. -- (58.178 /P964 /v.102)

Contents

    Table Of Contents:
    
    Contributors ix
    Preface xi
    Epigenetic Regulation of Gene Expression in Human Cells by Noncoding RNAs 1(10)
    Stuart Knowling
    Kevin V. Morris
    I Introduction to ncRNA 1(2)
    II Epigenetics and ncRNAs 3(1)
    III Long Intergenic Noncoding RNAs and Epigenetic Control of Gene Transcription 4(7)
    References 8(3)
    Small RNA-Induced Transcriptional Gene Regulation in Mammals: Mechanisms, Therapeutic Applications, and Scope Within the Genome 11(36)
    Victoria A. Green
    Marc S. Weinberg
    I Introduction 12(1)
    II Mammalian Small RNA Biogenesis Pathways 13(3)
    III Mechanisms of Small RNA-Induced Transcriptional Regulation 16(9)
    IV Therapeutic Application of TGS 25(5)
    V The Scope of TGS Therapeutics 30(7)
    VI Conclusions 37(10)
    References 38(9)
    MicroRNA Function in the Nervous System 47(54)
    Roberto Fiore
    Sharof Khudayberdiev
    Reuben Saba
    Gerhard Schratt
    I Introduction 48(1)
    II Mirnas In Neural Differentiation 49(11)
    III Mirnas In Postmitotic Neurons 60(9)
    IV The Roles of miRNA in Neurological Diseases 69(32)
    References 91(10)
    The Role of MicroRNAs in Viral Infection 101(40)
    Ashley P.E. Roberts
    Andrew P. Lewis
    Catherine L. Jopling
    I Introduction 102(6)
    II Regulation of miRNAs and Their Association with Disease 108(3)
    III Introduction to Viral Infection 111(2)
    IV Viral miRNAs 113(9)
    V Regulation of Cellular miRNAs by Viral Infection 122(5)
    VI Regulation of Viruses by Cellular miRNAs 127(3)
    VII Conclusions 130(11)
    References 131(10)
    Toward a Durable Treatment of HIV-1 Infection Using RNA Interference 141(24)
    Julia J.M. Eekels
    Ben Berkhout
    I RNAi: From Natural Pathway to Therapeutic Method 142(2)
    II Antiviral RNAi Strategies: Toward a Gene Therapy for HIV-1 144(3)
    III Where to Target the HIV-1 RNA Genome? 147(1)
    IV Combinatorial RNAi Approaches 148(1)
    V Targeting Cellular Cofactors of HIV-1 Replication 149(3)
    VI Preclinical Test Systems and Safety Concerns 152(1)
    VII Safety Issues Raised in Clinical Trials 153(1)
    VIII Gene Therapy Trials for HIV-AIDS 154(1)
    IX Conclusion 155(10)
    References 155(10)
    When Cellular Networks Run Out of Control: Global Dysregulation of the RNAi Machinery in Human Pathology and Therapy 165(78)
    Stefan Mockenhaupt
    Nina Schurmann
    Dirk Grimm
    I Introduction: Quis Custodiet Ipsos Custodes or Who Watches the Watchmen? 166(4)
    II Control of Individual miRNAs and RNAi Components 170(9)
    III Global Dysregulation of Key RNAi Factors in Human Disease 179(31)
    IV Quantitative Interference of Viruses with Host RNAi Factors 210(8)
    V Adverse Effects in Gene/RNAi Therapy Studies 218(11)
    VI Outlook: Relevance for Molecular Biology and Clinical Translation of RNAi 229(14)
    References 231(12)
    Index 243