Animal models in diabetes research / edited by Hans-Georg Joost, Hadi Al-Hasani, Annette Schurmann. — New York : Humana Press ; Springer, c2012. – (58.17/M592/v.933)

Contents

    CONTENTS
    
    Contributors
    PART I RODENT MODELS OF TYPE 1 DIABETES
    1 The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type I Diabetes 3
    2 Assessment of Diabetic Nephropathy in the Akita Mouse
    3 The BB Rat as a Model of Human Type 1 Diabetes
    PART II RODENT MODELS OF TYPE 2 DIABETES
    4 Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences
    5 Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome
    6 The TALLYHO Mouse as a Model of Human Type 2 Diabetes 75
    7 Diet-Induced Diabetes in the Sand Rat (Psammomys obes~s) 89
    8 Diabetes in Zucker Diabetic Fatty Rat 103
    9 The GK Rat: A Prototype for the Study of Non-overweight Type 2 Diabetes 125
    10 Experimentally Induced Rodent Models of Type 2 Diabetes 161
    PART III OTHER SPECIES
    11 Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates 177
    PART IV GENERAL METHODOLOGY
    12 Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets 189
    13 Determination of Beta-Cell Function: Ion Channel Function in Beta Cells 203
    14 Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests 219
    15 Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques 229
    16 Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro 255
    17 Beta-Cell Autoimmunity 265
    18 Positional Cloning of Diabetes Genes
    19 Retinal Digest Preparation: A Method to Study Diabetic Retinopathy 291
    20 Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration 303
    21 Genetic Lineage Tracing of Beta Cell Neogenesis 317
    Index 323