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Advances in genetics. v. 76 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin. — Amsterdam : Elsevier, c2011. – (58.14/A244/v.76)

Contents

    Contents
    
    Contributors vii
    1 Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)
    I. Introduction 2
    II. Chemosensation 7
    III. Mechanosensation 10
    IV. Peripheral Pain 15
    V. Conclusions 17
    References 17
    2 Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals 27
    I. Introduction 28
    II. The First Genetic Evidence for Introgression in Our Species 29
    III. Evidence for Introgression Obtained from Present-Day Human Genomes 30
    IV. History of Hominans in Europe 32
    V. Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA 37
    VI. The ABBA-BABA Test for Introgression 38
    VII. Different Regions of the Neanderthal Genome are Found in Different Modern Humans 4l
    VIII. The Genetic Contribution of the Denisovans to Our Species 44
    IX. Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans 45
    Acknowledgments 50
    References 50
    3 Genomic Approaches to Understanding Hox Gene Function 55
    I. Introduction: Historical Perspective 56
    II. The Molecular Genetics of Hox Complexes: Conservation and Colinearity 59
    III. Hox Target Genes and Functions 62
    IV. Early Experiments to Identify Hox Target Genes 65
    V. Genomic Approaches to Identifying Hox Target Genes 66
    VI. Microarray Expression Profiling 68
    VII. ChIP Approaches 73
    VIII. Computational Approaches 80
    IX. Prospects 81
    References 84
    4 GATA Transcription Factors in the Developing Reproductive System
    I. Introduction 94
    II. Molecular Control of Gonadal Development 99
    III. Canonical WNT Signaling Control of Gonadal Development 102
    IV. The GATA-FOG Transcriptional Partnership 103
    V. GATA4-FOG2 Control of Gonadal Development 105
    VI. Conclusions 119
    Acknowledgment 120
    References 120
    Index 135