Advances in genetics. v. 76 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin. — Amsterdam : Elsevier, c2011. – (58.14/A244/v.76) |
Contents
Contents
Contributors vii
1 Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)
I. Introduction 2
II. Chemosensation 7
III. Mechanosensation 10
IV. Peripheral Pain 15
V. Conclusions 17
References 17
2 Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals 27
I. Introduction 28
II. The First Genetic Evidence for Introgression in Our Species 29
III. Evidence for Introgression Obtained from Present-Day Human Genomes 30
IV. History of Hominans in Europe 32
V. Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA 37
VI. The ABBA-BABA Test for Introgression 38
VII. Different Regions of the Neanderthal Genome are Found in Different Modern Humans 4l
VIII. The Genetic Contribution of the Denisovans to Our Species 44
IX. Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans 45
Acknowledgments 50
References 50
3 Genomic Approaches to Understanding Hox Gene Function 55
I. Introduction: Historical Perspective 56
II. The Molecular Genetics of Hox Complexes: Conservation and Colinearity 59
III. Hox Target Genes and Functions 62
IV. Early Experiments to Identify Hox Target Genes 65
V. Genomic Approaches to Identifying Hox Target Genes 66
VI. Microarray Expression Profiling 68
VII. ChIP Approaches 73
VIII. Computational Approaches 80
IX. Prospects 81
References 84
4 GATA Transcription Factors in the Developing Reproductive System
I. Introduction 94
II. Molecular Control of Gonadal Development 99
III. Canonical WNT Signaling Control of Gonadal Development 102
IV. The GATA-FOG Transcriptional Partnership 103
V. GATA4-FOG2 Control of Gonadal Development 105
VI. Conclusions 119
Acknowledgment 120
References 120
Index 135