Progress in molecular biology and translational science. Volume 111, Genetics of stem cells. Part A / edited by Yaoliang Tang. — Amsterdam : Elsevier, c2012. – (58.178/P964/v.111)

Contents

    Contents
    
    Contributors
    Preface
    Generation of Induced Pluripotent Stem Cells from Somatic Cells
    I. Generation of iPSCs
    II. Methods of Delivering Transcription Factors into Cells
    III. Nongenetic Approaches for Reprogramming
    IV. Generation of Human iPSCs from Different Somatic Cell Types
    V. Characterization of iPSCs
    VI. Conclusion
    References
    Induced Pluripotent Cells in Cardiovascular Biology: Epigenetics， Promises， and Challenges
    I. Introduction 28
    II. Non-iPS-Cell-Based Therapies and Their Limitations 28
    III. Therapeutic Cloning and Embryonic Stem Cells 30
    IV. Induced Pluripotent Stem cells from Differentiated Somatic Cells 32
    V. Cardiovascular Lineage Differentiation of iPS Cells 38
    References 44
    Reprogramming of Somatic Cells
    I. Introduction 51
    II. Reprogramming of Somatic Ceils into Pluripotent Stem Cells 52
    III. Future Perspectives 72
    References 73
    Induction of Somatic Cell Reprogramming Using the MicroRNA miR-302
    I. Introduction
    II. Mechanism of Reprogramming
    III. Role of miR-302 in Early Embryogenesis
    IV. Dual Role of miR-302: Reprogramming Effector and Tumor Suppressor
    V. Balancing Stem Cell Tumorigenicity and Senescence
    VI. Conclusion
    References
    From Ontogenesis to Regeneration: Learning how to Instruct Adult Cardiac Progenitor Cells
    I. Regeneration: From Urodeles and Teleosts to Mammals
    II. To the "Heart" of the Problem
    III. Lessons from Development
    IV. Understanding the Stem Cell "Niche" and Its Roles..
    V. Recreating the Niche: The Importance of 3D Models
    VI. Cardiac Cell Therapy: The Era of Clinical Trials
    VII. Concluding Remarks
    Acknowledgment
    References
    Roles of MicroRNAs and Myocardial Cell Differentiation
    I. Introduction
    II. Myocardial Differentiation of ES Cells and miRNA
    III. Somatic Cell Reprogramming and miRNA
    IV. Heart Disease and MicroRNAs
    V. Conclusion
    References
    Wnt Signaling and Cardiac Differentiation
    I. Introduction
    II. Wnt Signaling
    III. Wnt Proteins and Cardiogenesis
    IV. Concluding Remarks
    Acknowledgments
    References
    Cross Talk Between the Notch Signaling and Noncoding RNA on the Fate of Stem Cells
    I. Introduction
    II. Direct Role of Notch Signaling in Stem Cell Maintenance and Differentiation
    III. Cross Talk Between MicroRNA and Notch Signal on Stem Cell Fate
    IV. Epigenetic Regulation of Stem Cell Fate via Notch Signaling..
    V. Conclusions
    Acknowledgements
    References
    Myocardial Regeneration: The Role of Progenitor Cells Derived from Bone Marrow and Heart
    I. Introduction
    II. Is There Cardiomyocyte Regeneration from Endogenous CPCs Post-MI?
    III. Paracrine Effects of Transplanted Cells in the Injured Heart
    IV. IGF + HGF Administration Can Activate In Situ CPCs to Generate Cardiomyocytes
    V. Do Transplanted BM-Derived and/or Transplanted or In Situ CPCs Transdifferentiate into Cardiomyocytes and Vascular Cells?..
    VI. Do CDCs and/or MSCs Stimulate Endogenous CPCs to Regenerate Cardiomyocytes and Vascular Cells?
    VII. Can Differentiated Cardiomyocytes Be Induced to Dedifferentiate and Reenter the Cell Cycle?
    VIII. Conclusions and Future Perspectives
    Acknowledgments
    References
    Role of GATA-4 in Differentiation and Survival of Bone Marrow Mesenchymal Stem Cells
    I. Introduction 218
    II. Cytotherapy in Myocardial Infarction 218
    III. Genetic Engineering of MSCs with Cytoprotective Factors 224
    IV. Conclusions 233
    References 235
    Progenitor Cell Mobilization and Recruitment: SDF-1， CXCR4， cx4-integrin， and c-kit
    I. Introduction 244
    II. Progenitor Cell Mobilization 244
    III. Progenitor Cell Recruitment and Retention 249
    IV. Therapeutic implications 251
    V. Summary 253
    Acknowledgment 253
    References 254
    Genetically Manipulated Progenitor/Stem Cells Restore Function to the Infarcted Heart Via the SDF-10~/CXCR4 Signaling Pathway
    I. Importance of SDF-I~ and CXCR4 Interaction in Ischemic Hearts
    II. Role of SDF-I~JCXCR4 as Therapeutic Targets in Heart Disease ..
    III. SDF-I~/CXCR4 as Therapeutic Targets in Vascular Diseases
    IV. Role of SDF-1WCXCR4 in Cell-Based Therapy
    V. Genetically Manipulated Cell Patch for Repair of Infarcted Myocardium
    VI. Conclusions
    Acknowledgments
    References
    Genetic Modification of Stem Cells for Cardiac， Diabetic， and Hemophilia Transplantation Therapies
    I. Introduction
    II. Genetic Engineering
    III. The Application of Genetic Modification of Stem Cells
    References
    Role of Heat Shock Proteins in Stem Cell Behavior
    I. Introduction
    II. Hsps in the Modulation of SC Self-Renewal
    III. Expression Profiles of Hsp in Differentiated SCs
    IV. Roles of Hsps in Tissue Genesis
    V. Protective Effects of Hsps in Transplanted SCs..
    VI. Roles of Hsps in SC Aging
    VII. Conclusions
    References
    Preconditioning Approach in Stem Cell Therapy for the Treatment of Infarcted Heart
    I. Introduction
    II. Stem Cell Therapy and the Heart
    III. Stem Cell Survival: Major Determinant of Efficacy of Stem Cell Therapy
    IV. Preconditioning: A Strategy to "Prime" the Cells for Improved Survival Under Stress
    V. Conclusions
    Acknowledgments
    References
    Index