Advances in virus research. v. 80 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy. — Amsterdam : Elsevier, c2011. – (58.679/A244/v.80)

Contents

    CONTENTS
    
    Contributors
    1. Mechanistic Intersections Between Picornavirus Translation and RNA Replication
    I. Background
    II. IRES-Dependent Translation and IRES-Transacting Factors
    III. Viral Modification of Canonical and Noncanonica Translation Factors
    IV. Important Aspects of RNA Replication
    V. Important RNA Elements in RNA Replication
    VI. Viral and Cellular Proteins Involved in RNA Replication
    VII. Alteration of Host Cell Environment and Implications for Replication
    VIII. The Switch from Viral Translation to Viral RNA Replication
    Acknowledgments
    References
    2. Mycoviruses， RNA Silencing， and Viral RNA Recombination
    I. Introduction
    II. Overcoming Technical Challenges to Mycovirus Research
    III. Antiviral Defense Mechanisms in Fungi
    IV. Regulation of the Fungal Antivira[ RNA Silencing Response
    V. RNA Silencing Contributes to Mycovirus RNA Recombination
    VI. Concluding Remarks
    References
    3. Viruses and Metabolism: Alterations of Glucose and Glutamine Metabolism Mediated by Human Cytomegalovirus
    I. The Warburg Effect and Cancer Cells
    II. Human Cytomegalovirus
    III. Glucose， Pyruvate， and Glutamine Metabolism in HCMV-Infected Cells
    IV. How does HCMV Accomplish These Alterations in Glucose and Glutamine Metabolism so that Glucose can be Used for Fatty Acid Synthesis?
    V. Conclusions and Discussion
    References
    4. Regulatory Roles of Protein Kinases in Cytomegalovirus Replication
    I. Introduction
    II. The Nature of Herpesviral Protein Kinases
    III. CrossTalk Between Herpesviral and Cellular Protein Kinases
    IV. Conclusions
    V. Outlook for Antiviral Research
    Acknowledgments
    References
    5. HIV Immune Evasion: Disruption of Antigen Presentation by the HIV Nef Protein
    I. Introduction to HIV-] Pathogenesis
    II. HIV-1 Nef
    III. Candidate Host Factors that Partner with Nef
    IV. Downmodulation of MHC-L Endocytic Mechanism
    V. Downmodulation of MHC-I; Evidence for Targeting of Newly Synthesized Protein in the Secretory Pathway
    VI. Summary
    Acknowledgments
    References
    Index
    Color plate section at the end of the book