Molecular machines in biology : workshop of the cell / edited by Joachim Frank. — ambridge ; New York : Cambridge University Press, 2011. – (58.6/M718)

Contents

    CONTENTS
    
    LIST OF CONTRIBUTORS vii
    LIST OF FIGURES AND TABLES ix
    PREFACE xiii
    INTRODUCTION 1
    Chap. 1 SINGLE-MOLECULE FRET: TECHNIQUE AND APPLICATIONS TO THE STUDIES OF MOLECULAR MACHINES 4
    Chap. 2 VISUALIZATION OF MOLECULAR MACHINES BY CRYO-ELECTRON MICROSCOPY 20
    Chap. 3 STATISTICAL MECHANICAL TREATMENT OF MOLECULAR MACHINES 38
    Chap. 4 EXPLORING THE FUNCTIONAL LANDSCAPE OF BIOMOLECULAR MACHINES VIA ELASTIC NETWORK NORMAL MODE ANALYSIS 59
    Chap. 5 STRUCTURE， FUNCTION， AND EVOLUTION OF ARCHAEO-EUKARYOTIC RNA POLYMERASES - GATEKEEPERS OF THE GENOME 78
    Chap. 6 SINGLE-MOLECULE FLUORESCENCE RESONANCE ENERGY TRANSFER INVESTIGATIONS OF RIBOSOME-CATALYZED PROTEIN SYNTHESIS 93
    Chap. 7 STRUCTURE AND DYNAMICS OF THE RIBOSOME AS REVEALED BY CRYO-ELECTRONMICROSCOPY 117
    Chap. 8 VIEWING THE MECHANISMS OF TRANSLATION THROUGH THE COMPUTATIONAL MICROSCOPE 142
    Chap. 9 THE RIBOSOME AS A BROWNIAN RATCHET MACHINE 158
    Chap. 10 THE GROEL/GROES CHAPERONIN MACHINE 191
    Chap. 11 ATP SYNTHASE - A PARADIGMATIC MOLECULAR MACHINE 208
    Chap. 12 ATP-DEPENDENT PROTEASES: THE CELL'S DEGRADATION MACHINES 239
    INDEX 261