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The functional fold : amyloid structures in nature / Suzi Jarvis, Anika Mostaert, editors. — Singapore :Boca Raton, FL : Pan Stanford ;CRC Press, c2012. – (58.174212/F979)

Contents

    Contents
    
    1. The World of Functional Amyloid
     1.1 Protein Misfolding and Aggregation
     1.2 Structural Properties of Amyloid
     1.3 Amyloid Formation Mechanisms
     1.4 Amyloid as a Pathological Entity
     1.5 Amyloid Is a Functional Protein Quaternary Structure
     1.6 Challenges and Future Directions
    2. Hagfish Slime Threads
     2.1 Introduction
     2.2 Are Hagfish Slime Threads "Disposable Amyloid"?
     2.3 Slime Threads Are Bundles of Intermediate Filaments
     2.4 Mechanical Properties
     2.5 Structural Considerations
    2.6 Implications for Other Materials Containing Intermediate Filaments
    2.7 Conclusions and Outlook
    3. Fungal Fibrils: Application of the Amyloid Polymer Structure by Fungi
     3.1 Introduction
    3.2 Early Observations of Rodlets
    3.3 The Two Classes of Hydrophobins
    3.4 Hydrophobins and Amyloid
    3.5 Structural Change During Rodlet Formation
    3.6 Specialization and Functional Significance of These Functional Amyloids
    3.7 Conclusions
    4. Silkmoth Chorion: A Natural Protective Amyloid
     4.1 Introduction
     4.2 Silkmoth Chorion Protein Peptide-Analogues
     4.3 Model Structure of Silkmoth Chorion Amyloidogenic Peptides
     4.4 Sikmoth Chorion: A Natural Protective Amyloid
    5. Spider Silk
     5.1 Introduction
     5.2 Overview of Silk Structure, Mechanics, and Assembly
     5.3 Conclusion
    6. Yeast Prions: Their Assembly into Protein Fibrils and the Role of Assembly Modulators
     6.1 Introduction
     6.2 Prions in Yeast
     6.3 The [PSI+], [PIN], [URE3], and [Her-s] Phenotypes
     6.4 In vitro Assembly of Sup35p, Rnq1p, Ure2p, and HET-s into Protein Fibrils
     6.5 Structural Basis of Yeast Prion Propagation
     6.6 Structural Models at an Atomic Resolution for Fibrillar Prion Proteins
     6.7 Molecular Chaperones and the Propagation of Yeast Prions
     6.8 Nature of the Infectious Form of Yeast Prions
     6.9 Conclusions and Outlook
    7. Curli Extracellular Matrix
     7.1 Bacterial Biofilms and the Curli Extracellular Matrix
     7.2 The Curli Gene Cluster
     7.3 From Regulation to Secretion
    7.4 Curli Biogenesis: Mechanism, Kinetics, and Fibril Structure
    7.5 Functional Role of Curli
    7.6 Summary
    8. Amyloid-Based Natural Adhesives and Cements
     8.1 Introduction to Natural Adhesives
     8.2 Amyloid in Natural Adhesives
     8.3 AFM as a Tool for Exploring Natural Adhesives
     8.4 Biomimetic Development of Amyloid - Inspired Adhesives
     8.5 Conclusions
    9. Mammalian Functional Amyloid
     9.1 Amyloid as a Structural and Regulatory Component of Haemostasis
     9.2 Amyloid Coordinates Melanin Biosynthesis in Mammals
     9.3 Conclusion
    10. Unfolding the Future
     10.1 The Field to Date
     10.2 The Challenge of Identification
     10.3 The Latest Discoveries
     10.4 Relevance to the Field of Pathogenic Amyloid
     10.5 Applications of Functional Amyloid
     10.6 Conclusions