Novel approaches to studying basal ganglia and related neuropsychiatric disorders / edited by Xiao-hong Lu. — Amsterdam : Elsevier, c2009. – (59.58/P526/v.89)

Contents

    CONTENTS
    
    CONTRIBUTORS
    PREFACE
    Molecular Profiling of Striatonigral and Striatopallidal Medium Spiny Neurons: Past， Present， and Future
    I. Introduction
    II. Early Detection of Neuropeptides and GPCRs in Striatonigral and Striatopallidal MSNs
    III. Current Methods for Molecular Profiling in the Two MSN Subtypes
    IV. The Next Stage for Genetic Profiling of the Two MSNs
    V. Use of BAC Transgenic Fluorescent Reporter Mice to Evaluate Molecular Pathways in the Two MSNs
    VI. Cell Type-Specific Overexpression and Knockout Models
    VII. Cell Type-Specific Mouse Models Evaluating Drug and Natural Reward
    VIII. Cell Type-Specific Mouse Models Evaluating Motor Behaviors
    IX. Cell Type-Specific Models Evaluating Protein Modifications
    X. Conclusions
    References
    BAC to Degeneration: Bacterial Artificial Chromosome (Bac)-Mediated Transgenesis for Modeling Basal Ganglia Neurodegenerative Disorders
    I. Introduction
    II. Concept and Advantages of the BAC Transgenesis Approach
    III. Generation of the BAC Transgenic Mice via Homologous Recombination
    IV. Technique Considerations and Possible Solutions
    V. BAC Transgenic Models of Basal Ganglia Neurodegenerative Disorders
    VI. BAC Transgenesis to Model Huntington's Disorder (HD)
    VII. BAC Transgenesis to Model Parkinson's Disease (PD)
    VIII. Modeling Neurodegenerative Diseases via BAC Transgenesis， A Future Perspective
    References
    Behavioral Outcome Measures for the Assessment of Sensorimotor Function in Animal Models of Movement Disorders
    I. Introduction
    II. Sensorimotor Tests for Unilateral 6-OHDA Rat
    III. Sensorimotor Tests for Genetic Mouse Models
    References
    The Role of DNA Methylation in the Central Nervous System and Neuropsychiatric Disorders
    I. Introduction
    II. DNA Methylation and DNA Methyltransferase
    III. DNA Methylation Mediates Gene Silencing
    IV. Role of DNA Methylation in the CNS and Neuropsychiatric Disorders
    V. Conclusion Remarks
    References
    Heritability of Structural Brain Traits: An Endophenotype Approach to Deconstruct Schizophrenia
    I. Introduction 86
    II. Heritability of Brain Structure Phenotypes 91
    III. Genes for Brain Structures in Healthy and Persons with Schizophrenia 107
    IV. Limitations and Clinical Relevance of the Studies 115
    References 121
    The Role of Striatal NMDA Receptors in Drug Addiction
    I. Introduction
    II. NMDA Receptors in the Striatum
    III. Role of Glutamate and NMDA Receptors in Drug Addiction
    IV. Neuropharmacological Studies and Clinical Implications
    References
    Deciphering Rett Syndrome With Mouse Genetics， Epigenomics， and Human Neurons
    I. Introduction
    II. RTT Mouse Models
    III. MeCP2 Expressions and Functions
    IV. MeCP2 and Gene Expression
    V. Posttranslational Modification of MeCP2
    VI. Epigenomics
    VII. Human Neuron-Based RTT Disease Model
    VIII. Summary.
    References
    INDEX
    CONTENTS OF RECENT VOLUMES