Handbook of epigenetics : the new molecular and medical genetics / edited by Trygve Tollefsbol. — Amsterdam : Elsevier, c2011. – (58.1481/H236)

Contents

                    CONTENTS
    
    CONTRIBUTORS
    PREFACE
    CHAPTER 1 Epigenetics: The New Science of Genetics 1
    SECTION I: Molecular Mechanisms of Epigenetics 7
    CHAPTER 2 Mechanisms of DNA Methylation， Methyl-CpG Recognition， and Demethylation in Mammals
    CHAPTER 3 Mechanisms of Histone Modifications 25
    SECTION II: Additional Epigenetic Processes 47
    CHAPTER 4 The Epigenetics of Non-coding RNA 49
    CHAPTER 5 Prions and Prion-like Phenomena in Epigenetic Inheritance 63
    CHAPTER 6 Chromosomal Position Effects and Gene Variegation: Impact in Pathologies
    CHAPTER 7 Polycomb Mechanisms and Epigenetic Control of Gene Activity 107
    SECTION III: Epigenetic Technology 123
    CHAPTER 8 Analysis of Gene-specific DNA Methylation 125
    CHAPTER 9 Methods for Assessing Genome-wide DNA Methylation 135
    CHAPTER 10 Methylation of Lysine 9 of Histone H3: Role of Heterochromatin Modulation and Tumorigenesis 149
    CHAPTER 11 Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus 159
    CHAPTER 12 Assessing Epigenetic Information 173
    SECTION IV: Model Organisms of Epigenetics 183
    CHAPTER 13 Epigenetics of Eukaryotic Microbes 185
    CHAPTER 14 Drosophila Epigenetics 203
    CHAPTER 15 Mouse Models of Epigenetic Inheritance 233
    CHAPTER 16 Epigenetic Regulatory Mechanisms in Plants 251
    SECTION V: Metabolism and Epigenetics 279
    CHAPTER 17 Metabolic Regulation of DNA Methylation in Mammals 281
    CHAPTER 18 Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 295
    SECTION VI: Functions of Epigenetics 313
    CHAPTER 19 Epigenetics， Stem Cells， and Cellular Differentiation 315
    CHAPTER 20 Epigenetic Basis of Skeletal Muscle Regeneration 329
    CHAPTER 21 Epigenetics of X Chromosome Inactivation 341
    CHAPTER 22 Genomic Imprinting 353
    CHAPTER 23 Epigenetics of Memory Processes 381
    CHAPTER 24 Transgenerational Epigenetics 391
    CHAPTER 25 Aging Epigenetics 405
    SECTION VII: Evolutionary Epigenetics 423
    CHAPTER 26 Epigenetics in Adaptive Evolution and Development: The Interplay Between Evolving Species and Epigenetic Mechanisms 425
    SECTION VIII: Epigenetic Epidemiology 447
    CHAPTER 27 The Effects of Diet on Epigenetic Processes 449
    CHAPTER 28 Environmental Agents and Epigenetics 459
    CHAPTER 29 Impact of Microbial Infections on the Human Epigenome and Carcinogenesis
    CHAPTER 30 DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome 495
    CHAPTER 31 Population Pharmacoepigenomics 511
    SECTION IX: Epigenetics and Human Disease 519
    CHAPTER 32 Cancer Epigenetics 521
    CHAPTER 33 The Role of Epigenetics in Immune Disorders 535
    CHAPTER 34 Epigenetics of Brain Disorders 553
    CHAPTER 35 Complex Metabolic Syndromes and Epigenetics 569
    CHAPTER 36 Imprinting Disorders in Humans 581
    SECTION X: Epigenetic Therapy 595
    CHAPTER 37 Clinical Applications of Histone Deacetylase Inhibitors 597
    INDEX 617
    COLOR PLATE SECTION