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新书资源(2012年3月)

The cell biology of stem cells / edited by Eran Meshorer, Kathrin Plath. — New York : Springer Science+Business Media, c2010. – (58.157/C393cb)

Contents

    CONTENTS
    
    1. EARLY EMBRYONIC CELL FATE DECISIONS IN THE MOUSE 1
    Abstract 1
    Introduction 1
    Lineage Establishment and the Pre-Stem Cell Program: Formation of the Blastocyst
    Lineage Maintenance and the Stem Cell Program: Beyond the Blastocyst 6
    The Second Lineage Decision: Subdividing the ICM 6
    Cell Signaling Regulates PE/EPI Specification 7
    Establishment and Modulation of Pluripotency in the EPI Lineage 9
    Conclusion 10
    2. NUCLEAR ARCHITECTURE IN STEM CELLS 14
    Abstract
    Introduction
    Functional Compartmentalization of the ES Cell Nucleus 15
    Stem Cell Features of Other Nucleoplasmic Subcompartments 19
    Chromatin Features Characteristic of ES Cell Nuclei 20
    Conclusion 22
    3. EPIGENETIC REGULATION OF PLURIPOTENCY 26
    Abstract
    Introduction
    Epigenetic Modifications
    The Epigenome of ES Cells
    Conclusion
    4. AUTOSOMAL LYONIZATION OF REPLICATION DOMAINS DURING EARLY MAMMALIAN DEVELOPMENT
    Abstract 41
    Introduction
    Replication Timing Program: An Elusive Measure of Genome Organization 42
    An Evolutionarily Conserved Epigenetic Fingerprint 48
    Replication Timing as a Quantitative Index of 3-Dimensional Genome Organization 49
    Replication Timing Reveals an Epigenetic Transition: Autosomal Lyonization at the Epiblast Stage 51
    Replication Timing and Cellular Reprogramming: Further Support for Autosomal Lyonization 52
    Maintenance and Alteration of Replication Timing Program and Its Potential Roles
    Conclusion 54
    5. PRESERVATION OF GENOMIC INTEGRITY IN MOUSE EMBRYONIC STEM CELLS 59
    Abstract 59
    Introduction and Historical Perspective 60
    Mutation Frequencies in Somatic Cells 62
    Protection of the Mouse ES Cell Genome 62
    Conclusion
    6. TRANSCRIPTIONAL REGULATION IN EMBRYONIC STEM CELLS 76
    Abstract 76
    Introduction 76
    Embryonic Stem Cells as a Model to Study Transcriptional Regulation
    Transcription Factors Governing ESC Pluripotency
    Transcriptional Regulatory Network
    Technologies for Dissecting the Transcriptional Regulatory Network 81
    The Core Transcriptional Regulatory Network: Oct4, Sox2 and Nanog 82
    Expanded Transcriptional Regulatory Network 84
    Enhanceosomes: Transcription Factor Complex 86
    Integration of Signaling Pathways to Transcriptional Network
    Interface Between Transcriptional and Epigenetic Regulation
    Conclusion
    7. ALTERNATIVE SPLICING IN STEM CELL SELF-RENEWAL AND DIFFERENTIATION 92
    Abstract
    Introduction
    Introduction to Alternative Splicing 93
    Alternative Splicing of Genes Impficated in Sternness and Differentiation 93
    Genome-Wide Methods to Identify and Detect Alternative Splicing Events 98
    Regulation of Alternative Splicing by RNA Binding Proteins 98
    Conclusion and Perspectives 101
    8. MicroRNA REGULATION OF EMBRYONIC STEM CELL SELF-RENEWAL AND DIFFERENTIATION
    Abstract 104
    Introduction: The Self-Renewal Program 105
    Embryonic Stem Cells
    miRNA Biogenesis and Function 106
    ESCC miRNAs Promote Self-Renewal 108
    miRNAs Induced during ESC Differentiation Suppress the Self-Renewal Program 110
    Regulatory Networks Controlling miRNA Expression 112
    miRNAs Can Promote or Inhibit Dedifferentiation to iPS Cells 113
    miRNAs in Somatic Stem Cells 113
    miRNAS in Cancer Cells 114
    Conclusion 114
    9. TELOMERES AND TELOMERASE IN ADULT STEM CELLS AND PLURIPOTENT EMBRYONIC STEM CELLS
    Abstract 118
    Introduction 119
    Regulation of Telomeres and Telomerase 120
    Role of Telomeres and Telomerase in Adult SC Compartments
    Telomeres and Telomerase Regulation during Reprogramming by SCNT
    Telomeres and Telomerase Regulation during iPS Cell Generation
    Telomerase Activation is Essential for the "Good" Quality of the Resulting iPS Cells
    Regulation of Telomere Reprogramming 126
    Conclusion 127
    10. X CHROMOSOME INACTIVATION AND EMBRYONIC STEM CELLS 132
    Abstract 132
    Introduction 132
    C/s Acting Factors in XCI 134
    Trans Acting Factors in XCI 136
    Counting and Choice 136
    Silencing and Maintenance of Silencing 141
    XCI and Human ES cells 144
    Conclusion 146
    11. ADULT STEM CELLS AND THEIR NICHES 155
    Abstract 155
    The Niche Concept, Definition and Historical Background 155
    Stem Cell Niche Components 157
    Molecular Pathways Associated with Niche Function 159
    Extracellular Matrix and Cell-Cell Interactions 160
    Stem Cell Niche Dynamism 161
    Stem Cell Niche Aging 162
    Malignant Stem Cell Niches 163
    Conclusion 164
    12. ADULT STEM CELL DIFFERENTIATION AND TRAFFICKING AND THEIR IMPLICATIONS IN DISEASE 169
    Abstract 169
    Differentiation 170
    Trafficking 174
    Conclusion 179
    13. VERTEBRATES THAT REGENERATE AS MODELS FOR GUIDING STEM CELLS 184
    Abstract 184
    Vertebrate Models of Regeneration: Their Attributes 184
    Regeneration Mechanisms of Mature Tissues 186
    Conclusion 206
    14. REPROGRAMMING OF SOMATIC CELLS TO PLURIPOTENCY 215
    Abstract 215
    Introduction 215
    Somatic Nuclear Reprogramming in Frog 216
    Birth of a Cloned Animal, Dolly 216
    Changing Cell Fate by Defined Factors, MyoD 216
    Reprogramming of Somatic Cells by Cell Fusion 217
    Generation of Induced Pluripotent Stem Cells by Sox2, Oct3/4, Klf4 and c-Myc 217
    Methods for Ips Cell Induction 219
    Molecular Mechanism for Ips Cell Generation 220
    Directed Cell Reprogramming: [3-Cells from Pancreatic Cells 220
    Directed Cell Reprogramming: Neuronal Cells from Fibroblasts 220
    Disease iPS Cells for Clinical Applications 221
    Conclusion 222
    INDEX 225