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Biostatistical methods : the assessment of relative risks / John M. Lachin. — 2nd ed. — Oxford : Wiley, 2011. – (61.517/L137/2nd ed.) |
Contents
CONTENTS
Preface
Preface to First Edition
1 Biostatistics and Biomedical Science
1.1 Statistics and the Scientific Method
1.2 Biostatistics
1.3 Natural History of Disease Progression
1.4 Types of Biomedical Studies
1.5 Studies of Diabetic Nephropathy
2 Relative Risk Estimates and Tests for Independent Groups
2.1 Probability as a Measure of Risk
2.2 Measures of Differential or Relative Risk
2.3 Large Sample Distribution
2.4 Sampling Models: Likelihoods
2.5 Exact Inference
2.6 Large Sample Inferences
2.7 SAS PROC FREQ
2.8 Other Measures of Differential Risk
2.9 Polychotomous and Ordinal Data
2.10 Two Independent Groups with Polychotomous Response
2.11 Multiple Independent Groups
2.12 Problems
3 Sample Size， Power， and Efficiency
3.1 Estimation Precision
3.2 Power of Z-Tests
3.3 Test for Two Proportions
3.4 Power of Chi-Square Tests
3.5 SAS PROC POWER
3.6 Efficiency
3.7 Problems
4 Stratified-Adjusted Analysis for Independent Groups
4.1 Introduction
4.2 Mantel-Haenszel Test and Cochran's Test
4.3 Stratified-Adjusted Estimators
4.4 Nature of Covariate Adjustment
4.5 Multivariate Tests of Hypotheses
4.6 Tests of Homogeneity
4.7 Efficient Tests of No Partial Association
4.8 Asymptotic Relative Efficiency of Competing Tests
4.9 Maximin-Efficient Robust Tests
4.10 Random Effects Model
4.11 Power and Sample Size for Tests of Association
4.12 Polychotomous and Ordinal Data
4.13 Problems
5 Case-Control and Matched Studies
5.1 Unmatched Case-Control (Retrospective) Sampling
5.2 Matching
5.3 Tests of Association for Matched Pairs
5.4 Measures of Association for Matched Pairs
5.5 Pair-Matched Retrospective Study
5.6 Power Function of McNemar's Test
5.7 Stratified Analysis of Pair-Matched Tables
5.8 Multiple Matching: Mantel-Haenszel Analysis
5.9 Matched Polychotomous Data
5.10 Kappa Index of Agreement
5.11 Problems
6 Applications of Maximum Likelihood and Efficient Scores
6.1 Binomial
6.2 2X2 Table: Product Binomial (Unconditionally)
6.3 2X2 Table， Conditionally
6.4 Score-Based Estimate
6.5 Stratified Score Analysis of Independent 2X2 Tables
6.6 Matched Pairs
6.7 Iterative Maximum Likelihood
6.8 Problems
7 Logistic Regression Models
7.1 Unconditional Logistic Regression Model
7.2 Interpretation of the Logistic Regression Model
7.3 Tests of Significance
7.4 Interactions
7.5 Measures of the Strength of Association
7.6 Conditional Logistic Regression Model for Matched Sets
7.7 Models for Polychotomous or Ordinal Data
7.8 Random Effects and Mixed Models
7.9 Models for Multivariate or Repeated Measures
7.10 Problems
8 Analysis of Count Data
8.1 Event Rates and the Homogeneous Poisson Model
8.2 Overdispersed Poisson Model
8.3 Poisson Regression Model
8.4 Overdispersed and Robust Poisson Regression
8.5 Conditional Poisson Regression for Matched Sets
8.6 Negative Binomial Models
8.7 Power and Sample Size
8.8 Multiple Outcomes
8.9 Problems
9 Analysis of Event-Time Data
9.1 Introduction to Survival Analysis
9.2 Lifetable Construction
9.3 Family of Weighted Mantel-Haenszel Tests
9.4 Proportional Hazards Models
9.5 Evaluation of Sample Size and Power
9.6 Additional Models
9.7 Analysis of Recurrent Events
9.8 Problems
Appendix Statistical Theory
A.1 Introduction
A.2 Central Limit Theorem and the Law of Large Numbers
A.3 Delta Method
A.4 Slutsky's Convergence Theorem
A.5 Least Squares Estimation
A.6 Maximum Likelihood Estimation and Efficient Scores
A.7 Tests of Significance
A.8 Explained Variation
A.9 Robust Inference
A.10 Generalized Linear Models and Quasi-likelihood
A.11 Generalized Estimating Equations (GEE)
References
Author Index
Subject Index
