Genetic epidemiology / edited by M. Dawn Teare. — New York ; London : Humana Press, c2011. – (58.17/M592/v.713) |
Contents
Contents
PART I INTRODUCTION
1 Molecular Genetics and Genetic Variation
2 Terminology, Concepts, and Models in Genetic Epidemiology
3 An Introduction to Epidemiology
PART II -GENETIC LINKAGE MAPPING
4 Genetic Distance and Markers Used in Linkage Mapping 43
5 Approaches to Genetic Linkage Analysis
PART III GENETIC MAPPING BY ASSOCIATION
6 Fine-Scale Structure of the Genome and Markers Used in Association Mapping
7 Genome-Wide Association Studies
8 Candidate Gene Association Studies 105
9 Family-Based Association Studies 119
10 Genome Variation: A Review of Web Resources
PART IV EMERGING THEMES
11 Advanced Methods in Twin Studies 143
12 Mendelian Randomisation: A Tool for Assessing Causality in Observational epidemiology 153
13 Copy Number Variation
14 Epigenetic Variation
PART V CASE STUDIES
15 Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis 201
16 Coronary Artery Disease: An Example Case Study 215
17 The Genetic Epidemiology of Obesity: A Case Study 227
Index 239