Protein kinase C in cancer signaling and therapy / Marcelo G. Kazanietz, editor. — New York : Springer, 2010. – (64.863/P967) |
Contents
Contents
Part I Regulation of PKC Isozyme Function: From Genes to Biochemistry
1 Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
2 Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
3 Phorbol Esters and Diacylglycerol: The PKC Activators
4 Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals 55
5 Regulation of PKC by Protein-Protein Interactions in Cancer
Part II PKC Isozymes in the Control of Cell Function
6 Introduction: PKC Isozymes in the Control of Cell Function 107
7 Regulation and Function of Protein Kinase D Signaling 1 ! 7
8 PKC and Control of the Cell Cycle
9 PKC and the Control of Apoptosis
10 Atypical PKCs, NF-κ.B, and Inflammation
Part III PKC Isozymes in Cancer
11 Introduction: PKC and Cancer
12 Protein Kinase C, p53, and DNA Damage
13 PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
14 PKC-PKD Interplay in Cancer
15 Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
16 PKC Isozymes and Skin Cancer
17 PKC and Breast Cancer 347
18 PKC and Prostate Cancer
19 Protein Kinase C and Lung Cancer
Part IV PKC Isozymes as Targets for Cancer Therapy
20 Introduction
21 PKC and Resistance to Chemotherapeutic Agents
22 PKC5 as a Target for Chemotherapeutic Drugs
23 Atypical PKCs as Targets for Cancer Therapy
Index