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新书资源(2011年6月)

Protein kinase C in cancer signaling and therapy / Marcelo G. Kazanietz, editor. — New York : Springer, 2010. – (64.863/P967)

Contents

    Contents
    
    Part I Regulation of PKC Isozyme Function: From Genes to Biochemistry
    1 Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
    2 Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
    3 Phorbol Esters and Diacylglycerol: The PKC Activators
    4 Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals 55
    5 Regulation of PKC by Protein-Protein Interactions in Cancer
    Part II PKC Isozymes in the Control of Cell Function
    6 Introduction: PKC Isozymes in the Control of Cell Function 107
    7 Regulation and Function of Protein Kinase D Signaling 1 ! 7
    8 PKC and Control of the Cell Cycle
    9 PKC and the Control of Apoptosis
    10 Atypical PKCs, NF-κ.B, and Inflammation
    Part III PKC Isozymes in Cancer
    11 Introduction: PKC and Cancer
    12 Protein Kinase C, p53, and DNA Damage
    13 PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
    14 PKC-PKD Interplay in Cancer
    15 Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
    16 PKC Isozymes and Skin Cancer
    17 PKC and Breast Cancer 347
    18 PKC and Prostate Cancer
    19 Protein Kinase C and Lung Cancer
    Part IV PKC Isozymes as Targets for Cancer Therapy
    20 Introduction
    21 PKC and Resistance to Chemotherapeutic Agents
    22 PKC5 as a Target for Chemotherapeutic Drugs
    23 Atypical PKCs as Targets for Cancer Therapy
    Index