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New insights to neuroimmune biology / Istvan Berczi. — Boston, MA : Elsevier, 2010. – (64.1/B486) |
Contents
Contents
Foreword
Preface
List of Contributors
Section A Introduction
1 The Brave New World of Neuroimmune Biology
1.1 Introduction
1.2 Recent Developments in Neuroimmune Biology
1.3 The NISS
1.4 Immunological Memory
1.5 Autonomy and Redundancy
1.6 Protection for Life by the Neuroimmune Supersystem
1.7 Conclusions
Section B History
2 On the History of lmmunophysiology: First Steps and Main Trends
2.1 Introduction
2.2 Early Investigations
2.3 The Second Period
2.4 Consolidation of the Science of Immunophysiology
2.5 Modern Immunophysiology
2.6 Historical Note to Figures: Initial Events in the Organization of Research Activities in Immunophysiology
2.7 Conclusions
Section C Molecular Regulation
3 Selective Pro-Inflammatory Activation of Astrocytes by High Mobility Group Box 1 Protein Signaling
3.1 Introduction
3.2 Proteomic Analysis of Astrocytes Stimulated with HMGB 1
3.3 Functional Properties of HMGBI-Activated Astrocytes
3.4 Conclusion
Acknowledgments
Section D Physiology
4 Choroid Plexus and Immune Response of the Brain
4.1 Introduction
4.2 Choroid Plexus: Basic Structure and Function
4.3 Choroid Plexus and the Immune System
4.4 Choroid Plexus and Brain Development
4.5 Choroid Plexus and Aging
4.6 Choroid Plexus and Neurodegeneration: Aizheimer's Disease as a Case in Point
4.7 Choroid Plexus as Transplantable Cells for Brain Repair: Pilot Studies
4.8 Encapsulated Choroid Plexus Cells as Immunoisolated Transplant Approach
4.9 Encapsulated Xenogeneic Choroid Plexus Transplants for Stroke Therapy
4.10 Encapsulated Xenogeneic Choroid Plexus Transplants for Huntington's Disease Therapy
4.11 In Vitro and In Vivo Determinations of the Effect of Age on CP Function
4.12 Conclusions
5 Role of the Sympathetic Nervous System in Immunity
5.1 Early Evidence for Nervous System-Immune System Communication
5.2 Innervation of Lymphoid Tissue
5.3 Release of Norepinephrine
5.4 Expression of the Beta-2-Adrenergic Receptor
5.5 Evidence that Norepinephrine Regulates Immune-Cell Function
5.6 NK Cells
5.7 Macrophages
5.8 Dendritic Cells
5.9 CD4+ T Cells
5.10 CD8+ T Cells
5.11 B Cell
5.12 Concluding Remarks
6 Circadian Organization of the Immune Response: Rat Adjuvant Arthritis as a Model
6.1 The Circadian Clock Has Indispensable Biological Functions
6.2 The Immune System Shows a Circadian Organization
6.3 "Sickness Behavior" Includes Changes in Circadian Rhythms
6.4 Rat Adjuvant Arthritis as an Experimental Model of Rheumatoid Arthritis
6.5 Conclusions
Acknowledgments
7 Antigenic Recognition by the Brain: The Brain as an Immunocompetent Organ
7.1 Introduction
7.2 The CNS Has Innate Immune Receptors to Sense Antigens Directly
7.3 Sensing Adaptive Immune Reactions by the CNS
7.4 Sensing and Regulating Inflammation: Mast Cells as Sensory and Neuroeffector Cells
7.5 Some Functions of the Sensory Nerve Mast Cell Pathway
7.6 Conclusions
Section E Pathophysiology
8 Neurogenic Inflammation and the "Inflammatory Reflex": Two Pathways of Immunoregulation by the Nervous System
8.1 Neurogenic Inflammation: A Spinal Cord Reflex to Initiate Immune Response
8.2 The "Inflammatory Reflex": A Mechanism to Counter-Regulate Immunological Inflammation
8.3 Conclusions
9 Role of Tachykinins in Asthma and Allergic Disease
9.1 Introduction
9.2 Localization and Production of Tachykinins in the Airways
9.3 Role of Tachykinins in Respiratory Pathophysiology
9.4 The Role of Tachykinins in Animal Models of Asthma
9.5 Conclusions
10 Modulation of Immune Response by Head Injury
10.1 Traumatic Brain Injury: Epidemiology
10.2 Primary and Secondary Brain Injury
10.3 Molecular Cascades Mediating Cell Death after TBI
10.4 Cellular Inflammatory Response and Axonal Damage
10.5 Cerebral Cytokine Network
10.6 Role of Chemokines in TBI
10.7 Anti-Inflammatory Intervention after TBI
10.8 Conclusions
Acknowledgments
11 Defence and Defeat Reaction: Central Control and Peripheral Effects
11.1 Introduction
11.2 Historical Landmarks
11.3 Extending the Pioneer's Findings and The Discovery of Neural-Immune Connection
11.4 Principal Organisation of The Defence and Defeat Reactions
11.5 The Complexity of Defence and Defeat Reaction in Modern Man
11.6 Concluding Remarks
Acknowledgements
Section F Behaviour
12 Cytokines， Behavior， and Affective Disorders
12.1 Introduction
12.2 Cytokines and Sickness Behavior
12.3 Specific Disorders in Which Cytokines May Produce Behavioral Effects
12.4 Cytokines and Affective Disorders
12.5 Concluding Remarks
13 Increased Type 1 Helper T Cell Functions and Reward Stimulation
13.1 Introduction: Psychological Variables Do Correlate with Immune Alterations
13.2 Neural Regulation of Immunity
13.3 Reward Center/Pleasure and NK Cells
13.4 Conclusion
