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The chemical biology of nucleic acids / edited by Gunter Mayer. — Oxford : Wiley, 2010. – (58.174256/C517)

Contents

    Contents
    
    1 Chemical Synthesis of Modified RNA
    2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs
    3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides
    4 Nucleic Acid-templated Chemistry
    5 Chemical Biology of Peptide Nucleic Acids (PNAs)
    6 The Interactions of Small Molecules with DNA and RNA
    7 The Architectural Motifs of Folded RNAs
    8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs)
    9 Small Non-coding RNA in Bacteria
    10 MicroRNA-guided Gene Silencing
    11 Nucleic Acid-based Therapies
    12 Innate Immune Recognition of Nucleic Acids
    13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes
    14 DNA Methylation
    15 Frameworks for Programming RNA Devices
    16 RNA as a Catalyst: The Diels-Alderase Ribozyme
    17 Evolving an Understanding of RNA Function by In Vitro Approaches
    18 The Chemical Biology of Aptamers: Synthesis and Applications
    19 Nucleic Acids as Detection Tools
    20 Bacterial Riboswitch Discovery and Analysis
    Index