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The metabolic pathway engineering handbook : fundamentals / editor, Christina D. Smolke. — Boca Raton : CRC Press/Taylor & Francis, 2010. – (58.21073/M587)

Contents

    Contents
    
    Introduction ix
    Editor xv
    Contributors
    SECTION I Cellular Metabolism
    1 Solute Transport Processes in the Cell
    2 Catabolism and Metabolic Fueling Processes
    3 Biosynthesis of Cellular Building Blocks: The Prerequisites of Life 3-1
    4 Polymerization of Building Blocks to Macromolecules Polyhydroxyalkanoates as an Example
    5 Rare Metabolic Conversions--Harvesting Diversity through Nature 5-1
    SECTION II Balances and Reaction Models
    6 Growth Nutrients and Diversity
    7 Mass Balances, Rates, and Experiments
    8 Data Reconciliation and Error Detection
    9 Black Box Models for Growth and Product Formation
    10 Metabolic Models for Growth and Product Formation
    11 A Thermodynamic Description of Microbial Growth and Product Formation
    SECTION III Bacterial Transcriptional Regulation of Metabolism
    12 Transcribing Metabolism Genes: Lessons from a Feral Promoter 12-1
    13 Regulation of Secondary Metabolism in Bacteria
    14 A Synthetic Approach to Transcriptional Regulatory Engineering 14-1
    SECTION IV Modeling Tools for Metabolic Engineering
    15 Metabolic Flux Analysis
    16 Metabolic Control Analysis
    17 Structure and Flux Analysis of Metabolic Networks
    18 Constraint-Based Genome-Scale Models of Cellular Metabolism
    19 Multiscale Modeling of Metabolic Regulation
    20 Validation of Metabolic Models
    SECTION V Developing Appropriate Hosts for Metabolic Engineering
    21 Escherichia coli as a Well-Developed Host for Metabolic Engineering
    22 Metabolic Engineering in Yeast
    23 Metabolic Engineering of Bacillus subtilis
    24 Metabolic Engineering of Streptomyces
    25 Metabolic Engineering of Filamentous Fungi
    26 Metabolic Engineering of Mammalian Ceils
    Index