The metabolic pathway engineering handbook : fundamentals / editor, Christina D. Smolke. — Boca Raton : CRC Press/Taylor & Francis, 2010. – (58.21073/M587) |
Contents
Contents
Introduction ix
Editor xv
Contributors
SECTION I Cellular Metabolism
1 Solute Transport Processes in the Cell
2 Catabolism and Metabolic Fueling Processes
3 Biosynthesis of Cellular Building Blocks: The Prerequisites of Life 3-1
4 Polymerization of Building Blocks to Macromolecules Polyhydroxyalkanoates as an Example
5 Rare Metabolic Conversions--Harvesting Diversity through Nature 5-1
SECTION II Balances and Reaction Models
6 Growth Nutrients and Diversity
7 Mass Balances, Rates, and Experiments
8 Data Reconciliation and Error Detection
9 Black Box Models for Growth and Product Formation
10 Metabolic Models for Growth and Product Formation
11 A Thermodynamic Description of Microbial Growth and Product Formation
SECTION III Bacterial Transcriptional Regulation of Metabolism
12 Transcribing Metabolism Genes: Lessons from a Feral Promoter 12-1
13 Regulation of Secondary Metabolism in Bacteria
14 A Synthetic Approach to Transcriptional Regulatory Engineering 14-1
SECTION IV Modeling Tools for Metabolic Engineering
15 Metabolic Flux Analysis
16 Metabolic Control Analysis
17 Structure and Flux Analysis of Metabolic Networks
18 Constraint-Based Genome-Scale Models of Cellular Metabolism
19 Multiscale Modeling of Metabolic Regulation
20 Validation of Metabolic Models
SECTION V Developing Appropriate Hosts for Metabolic Engineering
21 Escherichia coli as a Well-Developed Host for Metabolic Engineering
22 Metabolic Engineering in Yeast
23 Metabolic Engineering of Bacillus subtilis
24 Metabolic Engineering of Streptomyces
25 Metabolic Engineering of Filamentous Fungi
26 Metabolic Engineering of Mammalian Ceils
Index