Emerging cancer therapy : microbial approaches and biotechnological tools / edited by Arsenio M. Fialho and Ananda M. Chakrabarty. — Hoboken, N.J. : Wiley, c2010. – (64.86/E53)

Contents

    CONTENTS
    
    PREFACE
    CONTRIBUTORS
    PART I LIVE/ATTENUATED BACTERIA AND VIRUSES AS ANTICANCER AGENTS
    1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to Eradicate Them in Nude Mouse Models 3
    2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for the Treatment of Cancer
    3 Bacillus Calmette-Guerin (BCG) for Urothelial Carcinoma of the Bladder
    4 Live Clostridia: A Powerful Tool in Tumor Biotherapy
    5 Bifidobacterium as a Delivery System of Functional Genes for Cancer Gene Therapy
    6 Replication-Selective Viruses for the Treatment of Cancer 119
    7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy
    PART II BACTERIAL PRODUCTS AS ANTICANCER AGENTS
    8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus Intelligent Drug Design 181
    9 Arginine Deiminase and Cancer Therapy 199
    10 Cytosine Deaminase/5-Fluorocytosine Molecular Cancer Chemotherapy
    11 Bacterial Proteins Against Metastasis
    12 Pseudomonas Exotoxin A-Based Immunotoxins for Targeted Cancer Therapy
    13 Denileukin Diftitox in Novel Cancer Therapy
    14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment: Laboratory Investigations and Clinical Potential 309
    15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents
    16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy
    17 The Use of RNA and CpG DNA as Nucleic Acid-Based Therapeutics
    PART III PATENTS ON BACTERIA/BACTERIAL PRODUCTS AS ANTICANCER AGENTS
    18 The Role and Importance of Intellectual Property Generation and Protection in Drug Development
    INDEX