The brain and host defense / volume editor, Barry G. Arnason. — Amsterdam ; London : Elsevier, 2010. – (59.59/B814)

Contents

    Contents
    
    Foreword vii
    Preface xi
    List of Contributors x
    Section I
    Introduction 1
    1. The Hypothalamus is the Central Organ of Immunoregulation 3
    Section II Development and Function of the Neuroimmune System 11
    2. Leech Neuroimmune Signaling 13
    3. Morphogenesis of the Hypothalamus and Hypophysis 25
    4. A Novel Genus of Specialized Anti-Inflammatory and Pro-Resolution Lipid Mediators
    5. Neural and Non-Neural Stem Cells as Novel Therapeutic Modalities for Brain Injury
    6. The Role of the Toll-Like Receptors in Neuropathology 67
    7. Cytokines and the Immune-Neuroendocrine Network 79
    8. Orexin-Containing Neurons and the Immune System 91
    9. Central Pathways of Immunoregulation 101
    10. Brain Responses to Antigenic Challenges 113
    Section III Immunoregulation by the Nervous System 123
    11. Role of the Endocrine System 125
    12. Conditioning of Immune Reactions 131
    13. Gender Issues in Host Defense 145
    Section IV How the Brain Defends Itself 159
    14. Glial Cells in Brain Defense Mechanisms 161
    15. Immunologic Privilege and the Brain 169
    16. Immune Aspects of the Blood-Brain Barrier 183
    17. Neuroprotective Activities of CD4+CD25 Regulatory T Cells 197
    Section V The Role of the Brain in Host Defense in Disease States 211
    18. Fever as a Host Defense Mechanism 213
    19. Leukocytes as Mediators of Pain and Analgesia 237
    20. Tumor Necrosis Factor as a Neuroinflammatory Mediator in Alzheimer's Disease and Stroke: Molecular Mechanisms and Neuroinflammatory Imaging 251
    21. Multiple Sclerosis and Depression: A Neuroimmunological Perspective 269
    22. Infection and Sepsis 309
    23. Restoration of Neuroimmune Disturbances in Rats by Extra-High-Frequency Electromagnetic Irradiation of the Skin 321
    Subject Index 333
    Color figure insert at the Back of the Book