Enzyme technologies : metagenomics, evolution, biocatalysis and biosynthesis / edited by Wu-Kuang Yeh, Hsiu-Chiung Yang, James R. McCarthy. — Hoboken, N.J. : Wiley, c2010. – (58.25/E61e)

Contents

    CONTENTS
    
    Contributors
    Preface
    PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES
    1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products
    2 Directed Enzyme and Pathway Evolution
    3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs
    4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts
    PART B BIOCATALYTIC APPLICATIONS
    5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients
    6 Enzymatic Processes for the Production of Pharmaceutical Intermediates
    7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes
    PART C BIOSYNTHETIC APPLICATIONS
    8 Drug Discovery and Development by Combinatorial Biosynthesis
    9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics
    10 Pathway and Enzyme Engineering and Applications for Glycodiversification
    Index