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Perinatal stem cells / edited by Curtis L. Cetrulo, Kyle J. Cetrulo, Curtis L. Cetrulo Jr. — Hoboken, N.J. : Wiley-Blackwell, c2009. – (58.155/P445)

Contents

    CONTENTS
    
    PREFACE
    CONTRIBUTORS
    INTRODUCTION: PERINATAL STEM CELLS
    1 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE
     Introduction
     Hematopoietic Stem Cell Transplants: Adult Donor Collection
     Hematopoietic Stem Cell Transplants: Adult Donor Testing
     Hematopoietic Stem Cell Transplants: Recipient Issues
     Collection and Processing of Cord Blood Units
     Bone Marrow versus Single Cord Blood: Pediatric
     Bone Marrow versus Cord Blood: Adults
     Cord Blood Transplant: Advantages and Disadvantages
     Double Cord Blood Transplants: Ablative Regimens
     Double Cord Blood Transplant: Non-Myeloablative Regimens
     Chimerism
     Predicting the Winner
     Are Two Cords Better Than One?
     Other Experimental Strategies
     Summary
     References
    2 EXPANDING THE THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD HEMATOPOIETIC STEM CELLS
     Introduction: Hematopoietic Stem Cells, the Therapeutic Distributed Stem Cells in Umbilical Cord Blood
     Biological Barriers to Hematopoietic Stem Cell Therapy
     Umbilical Cord Blood: An Ideal Source of Therapeutic Hematopoietic Stem Cells
     Shortcomings of Ex Vivo HSC Expansion Strategies
     A Novel Strategy With Potential to Enable Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
     Acknowledgments
     References
    3 USE OF FETAL CELLS IN REGENERATIVE MEDICINE
     Introduction
     Principles of Tissue Engineering
     Cell Sources for Tissue Engineering
     Examples of Possible Use and Implications of Perinatal Stem Cells
     Placental Derived Stem Cells (Chorionic, Amniotic Membranes)
     Amniotic Derived Stem Cells (hAMSC/Placental!)
     Amniotic Fluid-Derived Stem Cells (Nonplacental!)
     Conclusion
     References
    4 PERINATAL STEM CELLTHERAPY
     The Fetus as Recipient for Pre- and Perinatal Stem Cell Transplantation
     Prenatal Cell Transplantation: Current Experience
     How Do We Improve the Success of Prenatal Stem Cell Transplantation?
     Mesenchymal Stem Cells for Prenatal Transplantation
     Fetal Gene Therapy as a New Strategy
     Current Issues of Postnatal Gene Therapy
     Prenatal Gene Therapy
     Animal Models of Prenatal Gene Therapy
     Fetal Gene Therapy Targeting Hematopoietic Stem Cells
     Safety Aspects of Prenatal Gene Therapy
     Ethical Considerations
     References
    5 UMBILICAL CORD MESENCHYMAL STEM CELLS
     Preparation and Culture of UC-MSC
     Characteristics-Properties and Bone Marrow Comparison
     UC-MSC as Feeder Layer for Expansion of Human Cells
     Clinical Indications for UC-MSC
     References
    6 WHARTON'S JELLY-DERIVED MESENCHYMAL STROMAL CELLS
     Mesenchymal Stromal Cells
     Immunophenotype of Mesenchymal Stromal Cells
     MSCs are Multipotent Cells
     MSC and Stromal Support of the Stem Cell Niche
     Defining Primitive Stromal Cells: Differences between Fetal and Adult MSCs
     Umbilical Cord MSCs
     Characterization of Wharton's Jelly Derived Cells
     Other MSC-Like Cells from Umbilical Cord
     Comparison of WJCs to Adult Derived MSCs
     In Vitro Differentiation of WJCs
     Comparison of WJCs to Fetal MSCs
     Transplantation of WJCs
     WJCs as Primitive Stromal Cells
     Summary
     Acknowledgments
     References
    7 PERINATAL ENDOTHELIAL PROGENITOR CELLS
     The Role of Vascular Stem Cells in Postnatal Blood Vessel Formation Endothelial Progenitor Cells and Postnatal Vasculogenesis
     Sources of Endothelial Progenitor Cells
     EPCs, Vasculogenesis and Angiogenesis
     EPCs and Tissue Engineering
     EPCs and Cardiovascular Tissue Engineering
     The Future: Vascularized Engineered Tissue
     References
    8 UMBILICAL CORD DERIVED MAST CELLS AS MODELS FOR THE STUDY OF INFLAMMATORY DISEASES
     Introduction
     Mast Cell Triggers
     Mast Cell Mediators
     Selective Release of Mast Cell Mediators
     Natural Mast Cell Secretion Inhibitors
     Mast-T Cell Interaction
     Inflammatory Skin Diseases
     Fibromyalgia Syndrome
     Asthma
     Inflammatory Arthritis
     Coronary Inflammation
     Ocular Hypersensitivity Reactions
     Conclusion
     References
    9 AMNIOTIC FLUID DERIVED STEM CELLS
     Introduction
     Amniotic Fluid Cells
     The Discovery of Stem Cells in Amniotic Fluid
     Cultivation of Amniotic Fluid Derived Stem Cells
     Characteristics of Amniotic Fluid Derived Stem Cells
     Differentiation Potential of Amniotic Fluid Stem Cells
     Amniotic Fluid as a Promising Alternative Source for Neural Stem Cells
     Current Applications of Amniotic Fluid Stem Cells in Therapy
     Amniotic Fluid Stem Cells Banking
     References
    10 AMNIOTIC EPITHELIAL STEM CELLS IN REGENERATIVE MEDICINE
     Introduction
     Amnion and Its Properties
     Isolation and Culture of hAE Cells
     Stem Cell Characteristics of Amniotic Epithelium-Derived Cells
     Differentiation of hAE Cells
     Future Directions
     Conclusions
     Acknowledgment
     References
    11 HUMAN UMBILICALVEIN ENDOTHELIAL CELLS AND HUMAN DERMAL MICROVASCULAR ENDOTHELIAL CELLS OFFER NEW INSIGHTS INTO THE RELATIONSHIP BETWEEN LIPID METABOLISM, ANGIOGENESIS, AND ABDOMINAL AORTIC ANEURYSM
     Human Umbilical Vein Endothelial Cells
     Role of Angiogenesis in the Pathophysiology of Disease
     HMG-CoA Reductase Inhibitors have Therapeutic Effects that are Both Dependent and Independent of Cholesterol Lowering
     Studies of the Effects of Statins on Angiogenesis Using Both In Vivo Models and In Vitro HUVEC and HDMEC Models for Angiogenesis
     References
    12 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA
     Introduction
     The Hematopoietic System
     Historical Perspective on Placental Hematopoiesis
     Development and Structure of the Mouse Placenta
     Hematopoietic Activity in the Mouse Placenta
     Phenotype of Placental HSCs
     Origin and Localization of Placental HSCs
     Summary and Future Directions
     References
    13 FETAL CELL MICROCHIMERISM, A LOW-GRADE NATURALLY OCCURRING CELLTHERAPY
     Introduction
     The Placenta is a Source of Stem Cells
     Transfer of Fetal Progenitor Cells During Gestation
     Fetal Progenitor Cells in Maternal Tissues
     Future Therapies
     References
    INDEX