Neurobiology of Huntingtons disease : applications to drug discovery / edited by Donald C. Lo, Robert E. Hughes. — Boca Raton, Fla. : CRC Press, c2011. – (64.143/N494)

Contents

    Contents
    
    Series Preface
    Preface
    Editors
    Contributors
    Chapter 1 Huntington's Disease: Clinical Features and Routes to Therapy 1
    Chapter 2 Huntington's Disease Pathogenesis: Mechanisms and Pathways 29
    Chapter 3 Protein Interactions and Target Discovery in Huntington's Disease 55
    Chapter 4 Target Validation for Huntington's Disease 85
    Chapter 5 High-Throughput and High-Content Screening for Huntington's Disease Therapeutics 121
    Chapter 6 Value of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington's Disease 147
    Chapter 7 Mouse Models for Validating Preclinical Candidates for Huntington’s Disease 165
    Chapter 8 Pharmaceutical Development for Huntington's Disease 197
    Chapter 9 RNA- and DNA-Based Therapies for Huntington's Disease 225
    Chapter 10 Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Huntington's Disease 255
    Chapter 11 Biomarkers to Enable the Development of Neuroprotective Therapies for Huntington's Disease
    Chapter 12 Huntington's Disease: Clinical Experimental Therapeutics 285
    Index 299