Functional plasticity and genetic variation : insights into the neurobiology of alcoholism / edited by Matthew T. Reilly and David M. Lovinger. — Amsterdam : Elsevier, c2010. – (59.58/P526/v.91)

Contents

    CONTENTS
    
    The Role of microRNAs in Drug Addiction: A Big Lesson from Tiny Molecules
    I. Introduction
    II. microRNA
    III. microRNA and Alcohol
    IV. Future Directions
    V. Conclusions
    References
    The Genetics of Behavioral Alcohol Responses in Drosophila
    I. Introduction
    II. Ethanol Exposure in Flies
    III. Genes and Biochemical Pathways Involved in Alcohol Responses
    IV. Neural Circuits Involved in Ethanol Responses
    V. Conclusions
    References
    Neural Plasticity， Human Genetics， and Risk for Alcohol Dependence
    I. Introduction
    II. Brain Plasticity
    III. The Case for Intermediate Phenotypes or Endophenotypes
    IV. Brain Morphology as an Endophenotype for Alcohol Dependence Risk
    V. Brain Functional Differences Familial Risk and Developmental Stage
    VI. Brain Structural and Functional Effects and Genetic Variation
    VII. Conclusions
    References
    Using Expression Genetics to Study the Neurobiology of Ethanol and Alcoholism
    I. introduction
    II. Genetic and Genomic Approaches in Alcohol Research
    III. Genetic Analysis of Gene Expression
    IV. Recognizing Biological Function in Genetical Genomics Studies
    V. Current Problems and Future Solutions
    Acknowledgments
    References
    Genetic Variation and Brain Gene Expression in Rodent Models of Alcoholism: Implications for Medication Development
    I. Alcohol Addiction， Genetic Susceptibility， and Neuroadaptation
    II. Animal Models and the Trajectory of Alcohol Addiction
    III. Acute Pharmacological Responses to Alcohol
    IV. Models of Genetic Susceptibility: Selected Rat Lines and Inbred Mouse Strains
    V. Modeling Addiction-Related Neuroadaptations by long-Term Alcohol Access or Forced Intoxication
    VI. Conclusions
    References
    Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice
    I. Introduction
    II. Quantitative Trait Locus Mapping in Mice
    III. High-Resolution QTL Mapping
    IV. QTG Identification
    V. In Vivo QFG Analyses
    VI. Epistatic and Environmental Considerations in QTL Mapping
    VII. Human Relevance of QTGs Identified in Mice
    VIII. General Conclusions
    Acknowledgments
    References
    Glutamate Plasticity in the Drunken Amygdala: The Making of an Anxious Synapse
    I. Introduction
    II. Use-Dependent Synaptic Plasticity
    III. Lateral/Basolateral Amygdala， Chronic Ethanol， and Glutamatergic mechanisms Associated with Plasticity initiation
    IV. Chronic Alcohol， Withdrawal， and the Expression of Synaptic Plasticity
    V. Ethanol-Dependent Plasticity of Additional Amygdala Neurotransmitter Systems
    VI. Conclusions and Future Directions
    Acknowledgments
    References
    Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area: Interaction with Intrinsic Ion Channels and Neurotransmitter Inputs
    I. Introduction
    II. The Mesolimbic DA System and Alcohol Drinking
    III. intrinsic and Synaptic Mechanisms Controlling DA Neuron Activity
    IV. Acute Ethanol Action on DA Neuron Activity
    V. Plastic Changes in DA Neuron Activity after Previous Ethanol Exposure
    VI. Concluding Remarks
    Acknowledgments
    References
    Alcohol and the Prefrontal Cortex
    I. Introduction
    II. Anatomy of the Prefrontal Cortex
    III. The Executive Function of the Prefrontal Cortex
    IV. Electrophysiological Properties of the PFC
    V. Neuromodulation of PFC Neuron Activity
    VI. Effects of Alcohol on PFC Neuron Function In Vitro Studies
    VII. Effects of Alcohol on PFC Neuron Function In Vivo Animal Studies
    VIII. Effects of Alcohol on PFC Neuron Function Human Studies
    IX. Summary
    References
    BK Channel and Alcohol， A Complicated Affair
    I. Introduction
    II. BK Channel Properties and Its Regulation by Alcohol
    III. BK Channels in the Striatum
    IV. Perspectives
    Reference
    A Review of Synaptic Plasticity at Purkinje Neurons with a Focus on Ethanol-Induced Cerebellar Dysfunction
    I. Introduction
    II. Functional Cerebellar Neuroanatomy
    III. Overview of Cerebellar Development
    IV. Synaptic Plasticity at Purkinje Cells
    V. Modulation of Cerebellar Synaptic Plasticity by Ethanol
    VI. Conclusions and Future Directions
    Acknowledgments
    References
    INDEX
    CONTENTS OF RECENT VOLUMES