Molecular biology of aging / edited by Leonard Guarente, Linda Partridge and Douglas Wallace. — New York ; Bloxham : Cold Spring Harbor Laboratory Press, 2008. – (59.51874/M718)

Contents

    Contents
    
    Preface
    1 The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases
    2 Sirtuins: A Universal Link between NAD， Metabolism， and Aging， 39
    3 Calorie Restriction in Lower Organisms， 73
    4 Evolutionary Theory in Aging Research， 95
    5 An Overview of the Biology of Aging: A Human Perspective， 113
    6 p53， Cancer， and Longevity， 127
    7 Aging Processes in Caenorhabditis elegans， 153
    8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging?， 185
    9 Genome-wide Views of Aging Gene Networks， 215
    10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments， 237
    11 Yeast， a Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging， 267
    12 DNA Repair and Aging， 309
    13 Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis， 347
    14 Alzheimer's Disease: Genetics， Pathogenesis， Models， and Experimental Therapeutics， 371
    15 How Does Caloric Restriction Increase the Longevity of Mammals?， 409
    16 Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress， 427
    17 Molecular Mechanisms of Aging: Insights from Budding Yeast， 483
    18 Genetics of Exceptional Longevity， 517
    19 Mammalian Metabolism in Aging， 545
    20 Telomeres and Telomerase in Aging and Cancer， 575
    Index， 599