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The sugar code : fundamentals of glycosciences / edited by Hans-Joachim Gabius. — Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], c2009. – (58.17422/S947) |
Contents
Contents
Part One Chemical Basis
1 The Biochemical Basis and Coding Capacity of the Sugar Code
2 Three-Dimensional Aspects of the Sugar Code 15
3 The Chemist's Way to Synthesize Glycosides 37
4 The Chemist's Way to Prepare Multivalency 53
5 Analytical Aspects: Analysis of Protein-Bound Glycans
Part Two Natural Glycosylation-Glycoproteins
6 N-Glycosylation 87
7 O-Glycosylation: Structural Diversity and Functions 111
8 Glycosylation of Model and 'Lower' Organisms 139
9 Glycosylphosphatidylinositol Anchors: Structure， Biosynthesis and Functions 155
Part Three Natural Glycosylation-Glycolipids， Proteoglycans and Chitin
10 Glycolipids 177
11 Proteoglycans 199
12 Chitin 217
Part Four Protein-Carbohydrate Interactions
13 Protein-Carbohydrate Interactions: Basic Concepts and Methods for Analysis 233
14 How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays
15 The History of Lectinology 261
16 Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) 269
17 Bacterial and Viral Lectins 279
18 Plant Lectins 301
19 Animal and Human Lectins 317
20 Routes in Lectin Evolution: Case Study on the C-Type Lectin-Like Domains 329
21 Carbohydrate-Carbohydrate Interactions 347
Part Five Biomedical Aspects and Case Studies
22 Diseases of Glycosylation 365
23 Animal Models to Delineate Glycan Functionality 385
24 Glycobiology of Fertilization and Early Embryonic Development 403
25 Glycans as Functional Markers in Malignancy? 419
26 Small Is Beautiful: Mini-Lectins in Host Defense 433
27 Inflammation and Glycosciences 447
28 Sugars as Pharmaceuticals 469
29 Platelet Glycoproteins as Lectins in Hematology 485
30 Neurobiology Meets Glycosciences 495
Glossary 517
Index 549
