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Hepatocytes : methods and protocols / edited by Patrick Maurel. — Totowa, N.J. : Humana ; London : Springer [distributor], c2010. – (58.17/M592/v.640)

Contents

    Contents
    
    Foreword
    Preface
    Contributors
    1. General Review on In Vitro Hepatocyte Models and Their Applications
    2. Human Foetal Hepatocytes: Isolation, Characterization, and Transplantation 41
    3. Isolation and Culture of Primary Hepatocytes from Resected Human Liver Tissue
    4. Optimisation of the Cryopreservation of Primary Hepatocytes 83
    5. Cryopreservation of Human Hepatocytes for Clinical Use 107
    6. Hepatocyte Differentiation 115
    7. Reversible Manipulation of Apoptosis Sensitivity in Cultured Hepatocytes by Matrix-Mediated Manipulation of Signaling Activities 139
    8. Markers and Signaling Factors for Stem Cell Differentiation to Hepatocytes: Lessons from Developmental Studies 157
    9. Hepatic Stem Cells
    10. Hepatic Stem Cells and Liver Development 181
    11. Generation of Hepatocytes from Human Embryonic Stem Cells 237
    12. Isolation and Culture of Adult Human Liver Progenitor Cells: In Vitro Differentiation to Hepatocyte-Like Cells 247
    13. The HepaRG Cell Line: Biological Properties and Relevance as a Tool for Cell Biology, Drug Metabolism, and Virology Studies 261
    14. Transdifferentiation of Pancreatic Cells to Hepatocytes 273
    15. Evaluation of Drug Metabolism, Drug-Drug Interactions, and In Vitro Hepatotoxicity with Cryopreserved Human Hepatocytes 281
    16. The Use of Human Hepatocytes to Investigate Drug Metabolism and CYP Enzyme Induction 295
    17. The Use of Hepatocytes to Investigate UDP-Glucuronosyltransferases and Sulfotransferases
    18. The Use of Hepatocytes to Investigate Drug Uptake Transporters 327
    19. Metabonomic Studies on Human Hepatocyte in Primary Culture 355
    20. The Application of HepRG Cells in Evaluation of Cytochrome P450 Induction Properties of Drug Compounds 375
    21. The Use of Hepatocytes to Investigate Drug Toxicity
    22. The Use of Human Hepatocytes to Investigate Bile Acid Synthesis 417
    23. Use of Human Hepatocytes to Investigate Blood Coagulation Factor 431
    24. Use of Human Hepatocytes to Investigate HCV Infection 447
    25. The Use of Hepatocytes to Investigate HDV Infection: The HDV/HepaRG Model 463
    26. Rodent Models of Liver Repopulation
    27. Chimeric Mice with Humanized Liver: Tools for tile Study of Drug Metabolism, Excretion, and Toxicity 491
    28. Bioartificial Liver Support Systems
    29. Human Hepatocyte Transplantation 525
    Subject Index 535