Gene transfer and the ethics of first-in-human research : lost in translation / Jonathan Kimmelman. — Cambridge : Cambridge University Press, c2010. – (63.49/K49)

Contents

    Contents
    
    Acknowledgments
    List of abbreviations
    1 Introduction: gene transfer lost in translation 1
    2 What is gene transfer? 8
    3 Safety， values， and legitimacy: the protean nature of risk in translational trials 31
    4 Taming uncertainty: risk and gene-transfer clinical research 51
    5 Succor or suckers? Benefit， risk， and the therapeutic misconception 72
    6 Looking backward: a model of value for translational trials 89
    7 The chasm: the ethics of initiating first-in-human clinical trials 110
    8 Tropic of cancers: gene transfer in resource-poor settings 132
    9 Great Expectations and Hard Times: expectation management in gene transfer 153
    10 Something in the sight adjusts itself: conclusions 178
    Epilogue 192
    Index 193