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Analgesia : methods and protocols / edited by Arpad Szallasi. — New York, N.Y. : Humana Press, c2010. – (58.17/M592/v.617) |
Contents
Contents
Foreword
Preface
Contributors
1. Alternatives to Mammalian Pain Models 1: Use of C. elegans for the Study of Volatile Anesthetics
2. Alternatives to Mammalian Pain Models 2: Using Drosophila to Identify Novel Genes Involved in Nociception
3. Animal Models of Acute Surgical Pain
4. Animal Models of Acute and Chronic Inflammatory and Nociceptive Pain
5. Noxious Heat Threshold Measured with Slowly Increasing Temperatures: Novel Rat Thermal Hyperalgesia Models
6. Locomotor Activity in a Novel Environment as a Test of Inflammatory Pain in Rats
7. Rationale and Methods for Assessment of Pain-Depressed Behavior in Preclinical Assays of Pain and Analgesia
8. Animal Models of Orofacial Pain
9. Migraine Models 105
10. Experimental Models of Visceral Pain
11. Human Correlates of Animal Models of Chronic Pain
12. Human Experimental Pain Models 1: The Ultraviolet Light UV-B Pain Model
13. Human Experimental Pain Models 2: The Cold Pressor Model
14. Human Experimental Pain Models 3: Heat/Capsaicin Sensitization and Intradermal Capsaicin Models
15. The Value of the Dental Impaction Pain Model in Drug Development 175
16. Live Cell Imaging for Studying G Protein-Coupled Receptor Activation in Single Cells 191
17. Recombinant Cell Lines Stably Expressing Functional Ion Channels 209
18. Ion Channels in Analgesia Research
19. Electrophysiological and Neurochemical Techniques to Investigate Sensory Neurons in Analgesia Research 237
20. The Genetics of Pain and Analgesia in Laboratory Animals 261
21. RT-PCR Analysis of Pain Genes: Use of Gel-Based RT-PCR for Studying Induced and Tissue-Enriched Gene Expression
22. Gene-Based Approaches in the Study of Pathological Pain
23. Linkage Analysis and Functional Evaluation of Inherited Clinical Pain Conditions
24. Rat Bone Marrow Stromal Cells and Oligonucleotides in Pain Research
25. Transplantation of Human Mesenchymal Stem Cells in the Study of Neuropathic Pain
26. Delivery of RNA Interference to Peripheral Neurons In Vivo Using Herpes Simplex Virus
27. Combination of Cell Culture Assays and Knockout Mouse Analyses for the Study of opioid Partial Agonism 363
28. Assessing Potential Functionality of Catechol- O-methyltransferase (COMT) Polymorphisms Associated with Pain Sensitivity and Temporomandibular Joint Disorders 375
29. Genetic Polymorphisms and Human Sensitivity to Opioid Analgesics 395
30. Molecular Assays for Characterization of Alternatively Spliced Isoforms of the Mu Opioid Receptor (MOR)
31. Inhalational Anesthetic Photolabeling
32. Measuring Membrane Protein Interactions Using Optical Biosensors
33. Proteomics and Metabolomics and Their Application to Analgesia Research 457
34. Preemptive Analgesia: Problems with Assessment of Clinical Significance 475
35. Standardization of Pain Measurements in Clinical Trials 483
36. Procedural Sedation and Analgesia Research
37. Non-invasive Transcranial Direct Current Stimulation for the Study and Treatment of Neuropathic Pain 505
38. Pain Imaging in the Emerging Era of Molecular Medicine
39. Current and Emerging Pharmacologic Therapies for Pain and Challenges Which Still Lay Ahead
Concluding Remarks
Index
