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新书资源(2010年7月)

Genetics and randomness / Anatoly Ruvinsky. — Boca Raton, Fla. ; London : CRC, c2010. – (58.14/R983)

Contents

    Contents
    
    Preface
    Chapter 1 Limits and uncertainty in nature and logic
    Limits of nature
    Quantum uncertainty principle
    Statistical mechanics and Brownian motion
    Randomness in mathematics
    Limits of reasoning: randomness and complexity as the general feature of nature and mind
    Summary
    Note
    References
    Chapter 2 Quantum fluctuations, mutations, and "fixation" of uncertainty 19
    Nature of genes and mutations: the early attempts 19
    Mutations and repair 29
     Types of mutations 29
     Keto-enol transitions and quantum uncertainty 30
     Induced mutations and DNA repair 34
    How do random molecular events like mutations become facts of life? 35
    Somatic and germ cell mutations 36
    Quantum uncertainty and unpredictability of life 37
    Other quantum phenomena and life 38
    Summary 38
    References 39
    Chapter 3 Recombination and randomness 41
    What is recombination? 41
    Crossing-over 44
    Molecular nature of recombination 49
    Distribution of cross-overs along chromosomes 50
    Meiotic recombination generates randomness 51
    Origin of meiosis and sex 52
    Recombination and chromosome rearrangements 53
    Genome transformations and speciation 54
    Intron-exon structure of eukaryotic genes: randomness again 56
    Arranged randomness and immune response 57
    Summary 59
    References 60
    Chapter 4 Uncertainty of development 63
    Phenotype and genotype 63
    Stochasticity of development: clones and twins 65
    Mosaics and chimeras 68
    Alternative splicing and variety of proteins 69
    Stochastic nature of gene activity 72
    Epigenetic basis of developmental variability 73
    Random gene inactivation events 77
    Random X chromosome inactivation 79
    Gene networks and canalization 81
    Types of randomness 84
    Summary 86
    References 88
    Chapter 5 Organized randomness 93
    Gregor Mendel's vision 93
    Random segregation, uncertainty, and combinatorial variability 99
    Genes and chromosomes that violate the law 101
    Why is the first Mendelian law so common?
    Randomness rules
    Summary
    References
    Chapter 6 Random genetic drift and "deterministic" selection 111
    The discovery of genetic drift 111
    Neutral mutations in evolution 122
    Is natural selection deterministic? 126
    Adaptations and stochastic processes in evolution 128
    Summary 131
    References 132
    Chapter 7 Life: Making uncertainty certain 135
    Order from chaos 136
    What is life? 140
    The old comparison: physics and biology 142
    Natural selection: biology and beyond 145
    Randomness: nuisance or essence? 148
    The reason and the consequence 150
    Summary 155
    References 156
    Index 159