Mouse models for drug discovery : methods and protocols / edited by Gabriele Proetzel and Michael V. Wiles. — Totowa, N.J. : Humana, c2010. – (58.17/M592/v.602) |
Contents
Contents
Preface
Contributors
1. Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains
2. The Sophisticated Mouse: Protecting a Precious Reagent 23
3. Genetically Engineered Mouse Models in Drug Discovery Research
4. Engineering the Mouse Genome to Model Human Disease for Drug Discovery 55
5. Profiling of Drug Action Using Reporter Mice and Molecular Imaging 79
6. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
7. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease 105
8. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans 119
9. Mouse Models of Type II Diabetes Mellitus in Drug Discovery 135
10. Cholesterol Absorption and Metabolism 157
11. Collagen-Induced Arthritis in Mice
12. Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening
13. Models of Metastasis in Drug Discovery 215
14. Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging 235
15. CML Mouse Model in Translational Research 253
Mouse Models for Studying Depression-Like States and Antidepressant Drugs.. 267
17. Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors 283
18. Experimental Models of Anxiety for Drug Discovery and Brain Research 299
19. Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology 323
20. Neuromuscular Disease Models and Analysis 347
21. Murine Model of Cutaneous Infection with Streptococcus pyogenes 395
22. Murine Model of Pneumococcal Pneumonia 405
23. Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP) 411
Index 417