首页 > 新书资源
新书资源(2010年5月)

Immunotoxicity testing : methods and protocols / edited by Rodney R. Dietert. — New York : Springer, 2010. – (58.17/M592/v.598)

Contents

    Contents
    
    Preface
    Contributors
    PART I INTRODUCTION
    1 Immunotoxicology Testing: Past and Future
    PART II OVERVIEW AND HEALTH-RISK CONSIDEI~ITIONS
    2 Developmental Immunotoxicity (DIT): Tile Why, When, and How of DIT Testing
    3 An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds
    4 Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing
    5 Markers of Inflammation
    6 Evaluating Macrophages in Immunotoxicity Testing
    PART III IMMUNOTOXICITY AND HOST RESISTANCE MODELS
    7 Host Resistance Assays Including Bacterial Challenge Models
    8 Viral Host Resistance Studies
    9 Parasite Challenge as Host Resistance Models for Immunotoxicity Testing
    10 Tumor Challenges in Immunotoxicity Testing
    PART IV TESTING PROTOCOLS IN RODENTS AND OTHER LABORATORY ANIMALS
    11 The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents
    12 The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)
    13 The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens
    14 Tile Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function
    15 NK Cell Assays in Immunotoxicity Testing
    16 The Local Lymph Node Assay and Skin Sensitization Testing
    17 Use of Contact Hypersensitivity in Immunotoxicity Testing
    18 Evaluation of Apoptosis in Immunotoxicity Testing
    19 Dendritic Cells in Immunotoxicity Testing
    20 Evaluating Cytokines in Immunotoxicity Testing
    21 Flow Cytometry in Preclinical Drug Development
    22 Enhanced Histopathology Evaluation of Lymphoid Organs
    23 Immunotoxicity Testing in Nonhuman Primates
    PART V EVALUATION IN HUMANS
    24 Fundamentals of Clinical Immunotoxicology
    PART VI WILDLIFE TESTING
    25 In Vivo Functional Tests for Assessing Immunotoxicity in Birds
    PART VII IN VITRO ALTERNATIVES
    26 In Vitro Testing for Direct Immunotoxicity: State of the Art
    Index