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Advances in immunology. v. 104 / edited by Frederick W. Alt. — Amsterdam : Elsevier, c2009. – (58.691/A244/v.104)

Contents

    Contributors
    
    1. Regulation of Gene Expression in Peripheral T Cells by Runx Transcription Factors
     1. Introduction
     2. Multiple Factors Regulate Transcription in Eukaryotic Organisms
     3. Runx Proteins as Transcriptional Regulators
     4. Runx Proteins Regulate Thymic T-Cell Development
     5. Runx1 and Runx3 at the Cd4 Silencer
     6. Runx Proteins Regulate Peripheral CD4+ T-Cell Differentiation: The TH1/TH2 Paradigm
     7. Runx Proteins and iTREG/TH17 Differentiation
     8. Runx Proteins and the Differentiation of Effector CD8+ T Cells
     9. Concluding Remarks--Runx Proteins in Human Disease and Immunity
     Acknowledgments
     References
    2. Long Noncoding RNAs: Implications for Antigen Receptor Diversification
     1. Introduction
     2. Noncoding RNAs
     3. ncRNAs and the Adaptive Immune System
     4. Perspective
     References
    3. Pathogenic Mechanisms of Allergic Inflammation : Atopic Asthma as a Paradigm
     1. Introduction
     2. Development of Asthma-Related Phenotypes in Early Life
     3. Dendritic Cells and Asthma
     4. T-Regulatory (Treg) Cells
     5. Interactions Between Anti-viral and Atopic Inflammatory Pathways: Insight From Studies on Acute Severe Asthma Exacerbations in School Children
     6. The Search for New Asthma Drug Targets within the Th2 Cascade
     References
    4. The Amplification Loop of the Complement Pathways
     1. The Amplification Loop: The C3b Feedback and Breakdown Cycles
     2. The Evolutionary History of Complement
     3. The Alternative Pathway: A Rate-Governed Reaction
     4. Regulation of the C3b Breakdown Cycle
     5. Immunopathology of the Alternative Pathway
     Acknowledgments
     References
    Index
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