Chemogenomics : methods and applications / edited by Edgar Jacoby. — New York : Humana Press, c2009. – (58.17/M592/v.575)

Contents

    Contents
    
    Preface
    Contributors
    1 Organizing Bioactive Compound Discovery in Target Families
    2 Compound Library Design for Target Families..
    3 Targeting the Purinome
    4 Cofactor Chemogenomics
    5 Chemogenomics with Protein Secondary-Structure Mimetics
    6 Database Systems for Knowledge-Based Discovery 159
    7 Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein Interaction 173
    8 Off-Target Networks Derived from Ligand Set Similarity 195
    9 Chemogenomic Analysis of Safety Profiling Data
    10 Network and Pathway Analysis of Compound-Protein Interactions 225
    11 The Flexible Pocketome Engine for Structural Chemogenomics 249
    12 Structure-Based Chemogenomics: Analysis of Protein Family Landscapes 281
    13 Hypothesis-Driven Screening 297
    Index