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High throughput screening : methods and protocols / edited by William P. Janzen and Paul Bernasconi. — 2nd ed. — Dordrecht ; London : Humana Press, c2009. – (58.17/M592/v.565)

Contents

    Contents
    
    Preface
    Contributors
    1. Design and Implementation of High-Throughput Screening Assays
    2. Creation of a Small High-Throughput Screening Facility
    3. Informatics in Compound Library Management
    4. Statistics and Decision Making in High-Throughput Screening
    5. Enzyme Assay Design for High-Throughput Screening
    6. Application of Fluorescence Polarization in HTS Assays
    7. Screening G Protein-Coupled Receptors: Measurement of Intracellular Calcium Using the Fluorometric Imaging Plate Reader
    8. High-Throughput Automated Confocal Microscopy Imaging Screen of a Kinase-Focused Library to Identify p38 Mitogen-Activated Protein Kinase Inhibitors Using the GE InCell 3000 Analyzer
    9. Recent Advances in Electrophysiology-Based Screening Technology and the Impact upon Ion Channel Discovery Research 187
    10. Automated Patch Clamping Using the QPatch
    11. High-Throughput Screening of the Cyclic AMP-Dependent Protein Kinase (PKA) Using the Caliper Microfluidic Platform
    12. Use of Primary Human Cells in High-Throughput Screens
    Index