Principles and practice of bioanalysis / [edited by] Richard F. Venn. — 2nd ed. — Boca Raton, Fla. : CRC ; London : Taylor & Francis [distributor], 2008. – (63.324/P957/2nd ed.)

Contents

    Contents
    
    Preface to the Second Edition vii
    Preface to the First Edition ix
    About the Editor xi
    Contributors xiii
    Chapter 1 Physicochemical Properties of Drugs and Metabolites and Their Impact on Bioanalysis
    Chapter 2 Sample Preparation 19
    Chapter 3 Basic HPLC Theory and Pra6tice 41
    Chapter 4 HPLC Optimisation 69
    Chapter 5 HPLC Detectors 99
    Chapter 6 Gas Chromatography: What It Is and How We Use It 123
    Chapter 7 Thin-Layer Chromatography 141
    Chapter 8 Immunoassay Techniques 151
    Chapter 9 Automation of Sample Preparation 177
    Chapter 10 Fundamental Aspects of Mass Spectrometry 193
    Chapter 11 Quantitative LC-MS 223
    Chapter 12 Mass Spectrometric Identification of Metabolites 237
    Chapter 13 Nuclear Magnetic Resonance in Drug Metabolism 261
    Chapter 14 Metabolite Isolation 285
    Chapter 15 Strategy for the Development of Quantitative Bioanalytical Procedures
    Index 317