International review of cell and molecular biology. v. 273 / edited by Kwang W. Jeon. — Amsterdam : Elsevier, c2009. – (58.15/I61/v.273)

Contents

    CONTENTS
    
    Contributors
    1. Cellular Mechanism for Targeting Heterochromatin Formation in Drosophila
     1. Introduction
     2. Heterochromatin Domains in the Drosophila Genome
     3. DNA Sequences that Target Heterochromatin
     4. Histone Modifications and Heterochromatin Targeting
     5. Nonhistone Proteins and Heterochromatin Targeting
     6. Nuclear Associations and Heterochromatin in Drosophila
     7. Summary and Perspectives
     References
    2. Import of Nuclear-Encoded Mitochondrial Proteins: A Cotranslational Perspective
     1. Introduction
     2. Mitochondrial Assembly and Protein Import
     3. Mitochondrial Protein Import: Posttranslational or Cotranslational?
     4. Conclusions and Perspectives
     References
    3. Giant Siliceous Spicules From the Deep-Sea Glass Sponge Monorhaphis chuni
     1. Introduction
     2. Monorhaphis
     3. Giant Basal Spicules: Morphology--Chemistry—Mechanics
     4. Synthesis of Spicules in Demospongiae
     5. Spicule Network in Sponges: A Unique Skeleton
     6. Importance of the Findings for Nanobiotechnological Applications
     7. Concluding Remarks
     References
    4. The Biology of Caveolae: Achievements and Perspectives
     1. Introduction
     2. Structure of Caveolae
     3. Functions of Caveolae
     4. Caveolin-1 and Caveolae as Therapeutic Targets
     5. Concluding Remarks
     References
    5. Pharmacology of Ciliated Protozoa--Drug(In)Sensitivity and Experimental Drug (Ab)Use
     1. Introduction
     2. Early Success Story--Calmodulin and Its Effect on Ion Transport
     3. Cation Channels， Pumps， and Exchangers
     4. Functions of Specific Components
     5. Cytoskeleton
     6. Signaling， Intracellular Trafficking， and Signal Transduction
     7. Other Factors and Tools
     8. Concluding Remarks
     References
    6. Cell and Molecular Biology of Nuclear Actin
     1. Introduction
     2. Biological Functions of Nuclear Actin
     3. Mechanisms of Actin Function in the Nucleus
     4. Concluding Remarks
     References
    7. Small Ubiquitin-Like Modifiers in Cellular Malignancy and Metastasis
     1. Introduction
     2. SUMOs and SUMO-Modifying Enzymes
     3. Roles of SUMOs in Cancer Development， Progression， and Metastasis
     4. Concluding Remarks
     References
    8. Phosphoinositide Signaling Pathways: Promising Role as Builders of Epithelial Cell Polarity
     1. Introduction
     2. Phosphoinositides: Structure， Metabolism， and Functions
     3. Phosphoinositides as Key Determinants in Building Polarity
     4. Concluding Remarks
     References
    Index